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Engineered hydrogels for brain tumor culture and therapy
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Jai Thakor, Samad Ahadian, Ali Niakan, Ethan Banton, Fatemeh Nasrollahi, Mohammad M. Hasani-Sadrabadi, Ali Khademhosseini. Engineered hydrogels for brain tumor culture and therapy[J]. Journal of Zhejiang University Science D, 2020, 3(3): 203-226.
@article{title="Engineered hydrogels for brain tumor culture and therapy",
author="Jai Thakor, Samad Ahadian, Ali Niakan, Ethan Banton, Fatemeh Nasrollahi, Mohammad M. Hasani-Sadrabadi, Ali Khademhosseini",
journal="Journal of Zhejiang University Science D",
volume="3",
number="3",
pages="203-226",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00084-6"
}
%0 Journal Article
%T Engineered hydrogels for brain tumor culture and therapy
%A Jai Thakor
%A Samad Ahadian
%A Ali Niakan
%A Ethan Banton
%A Fatemeh Nasrollahi
%A Mohammad M. Hasani-Sadrabadi
%A Ali Khademhosseini
%J Journal of Zhejiang University SCIENCE D
%V 3
%N 3
%P 203-226
%@ 1869-1951
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00084-6
TY - JOUR
T1 - Engineered hydrogels for brain tumor culture and therapy
A1 - Jai Thakor
A1 - Samad Ahadian
A1 - Ali Niakan
A1 - Ethan Banton
A1 - Fatemeh Nasrollahi
A1 - Mohammad M. Hasani-Sadrabadi
A1 - Ali Khademhosseini
J0 - Journal of Zhejiang University Science D
VL - 3
IS - 3
SP - 203
EP - 226
%@ 1869-1951
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00084-6
Abstract: brain tumors’ severity ranges from benign to highly aggressive and invasive. bioengineering tools can assist in understanding the pathophysiology of these tumors from outside the body and facilitate development of suitable antitumoral treatments. Here, we first describe the physiology and cellular composition of brain tumors. Then, we discuss the development of three-dimensional tissue models utilizing brain tumor cells. In particular, we highlight the role of hydrogels in providing a biomimetic support for the cells to grow into defined structures. Microscale technologies, such as electrospinning and bioprinting, and advanced cellular models aim to mimic the extracellular matrix and natural cellular localization in engineered tumor tissues. Lastly, we review current applications and prospects of hydrogels for therapeutic purposes, such as drug delivery and co-administration with other therapies. Through further development, hydrogels can serve as a reliable option for in vitro modeling and treatment of brain tumors for translational medicine.
Open peer comments: Debate/Discuss/Question/Opinion
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