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On-line Access: 2020-01-24

Received: 2019-12-19

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Bio-Design and Manufacturing  2020 Vol.3 No.1 P.60-70


Guided cell migration on a graded micropillar substrate

Author(s):  Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu

Affiliation(s):  Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX 79409, USA; more

Corresponding email(s):   changxue.xu@ttu.edu

Key Words:  Guided cell migration, Graded microtopography, Cell polarization

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Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu. Guided cell migration on a graded micropillar substrate[J]. Journal of Zhejiang University Science D, 2020, 3(1): 60-70.

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author="Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu",
journal="Journal of Zhejiang University Science D",
publisher="Zhejiang University Press & Springer",

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%T Guided cell migration on a graded micropillar substrate
%A Srikumar Krishnamoorthy
%A Zhengyi Zhang
%A Changxue Xu
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%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00059-7

T1 - Guided cell migration on a graded micropillar substrate
A1 - Srikumar Krishnamoorthy
A1 - Zhengyi Zhang
A1 - Changxue Xu
J0 - Journal of Zhejiang University Science D
VL - 3
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SP - 60
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PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-020-00059-7

Cell migration is facilitated by the interaction of living cells and their local microenvironment. The local topography is one of the key factors regulating cell migration. Interaction between the surface topography and the cell behaviors is critical to understanding tissue development and regeneration. In this study, a dynamic mask photolithography technique has been utilized to fabricate a surface with graded micropillars. It has been demonstrated that the cells have been successfully guided to migrate from the sparse zone to the dense zone. The cell polarization angle has been characterized in both sparse zone and the dense zone. Compared to the dense zone, the cells in the sparse zone are more aligned along the direction of the micropillar spacing gradient, which enables the guided cell migration. Moreover, the efects of the micropillar spacing gradient, micropillar diameter, and micropillar height have been investigated in terms of the cell migration speed and cell spreading area. Finally, two issues signifcantly afecting the cell migration have been discussed: trapped cells between the micropillars and cell clusters.

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