Full Text:   <1755>

CLC number: 

On-line Access: 2021-01-21

Received: 2020-07-19

Revision Accepted: 2020-10-17

Crosschecked: 0000-00-00

Cited: 0

Clicked: 2395

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2021 Vol.4 No.3 P.612-626

http://doi.org/10.1007/s42242-020-00105-4


pH-sensitive polymeric nanocarriers for antitumor biotherapeutic molecules targeting delivery


Author(s):  Jiayi Qin, Yangbo Zhu, Dongsheng Zheng & Qingwei Zhao

Affiliation(s):  The First Affiliated Hospital, Zhejiang University School of Medicine, #79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China

Corresponding email(s):   qwzhao@zju.edu.cn

Key Words:  pH-sensitive polymeric nanocarrier, Acid-liable linkage, Antitumor biotherapeutic molecules, Targeting delivery, Pharmacokinetics


Share this article to: More

Jiayi Qin, Yangbo Zhu, Dongsheng Zheng & Qingwei Zhao. pH-sensitive polymeric nanocarriers for antitumor biotherapeutic molecules targeting delivery[J]. Journal of Zhejiang University Science D, 2021, 4(3): 612-626.

@article{title="pH-sensitive polymeric nanocarriers for antitumor biotherapeutic molecules targeting delivery",
author="Jiayi Qin, Yangbo Zhu, Dongsheng Zheng & Qingwei Zhao",
journal="Journal of Zhejiang University Science D",
volume="4",
number="3",
pages="612-626",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00105-4"
}

%0 Journal Article
%T pH-sensitive polymeric nanocarriers for antitumor biotherapeutic molecules targeting delivery
%A Jiayi Qin
%A Yangbo Zhu
%A Dongsheng Zheng & Qingwei Zhao
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 3
%P 612-626
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00105-4

TY - JOUR
T1 - pH-sensitive polymeric nanocarriers for antitumor biotherapeutic molecules targeting delivery
A1 - Jiayi Qin
A1 - Yangbo Zhu
A1 - Dongsheng Zheng & Qingwei Zhao
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 3
SP - 612
EP - 626
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00105-4


Abstract: 
pH-sensitive smart polymeric nanocarriers have been under development in the field of biomedicine due to permeabilization the physiological barriers readily to address the limitation of conventional chemotherapeutics delivery systems of low intracellular transport and targeting efficiency. Where traditional polymers kept stable under physiological neutral or acidic conditions, pH-sensitive polymeric nanocarriers underwent rapid degradation with a labile group in tumor acidic environment (around 5.06.0), allowing these biomaterials to achieve controlled drug release, drug pharmacokinetics improvement and antitumor biotherapeutic molecules efficiency enhancement compared with traditional polymers. This review mainly concentrated on properties of pH-sensitive polymers for biomedical purposes to construct the smart drug delivery system based on acid liable linkers which were categorized into pH-sensitive polymeric prodrugs composed of antitumor drugs (doxorubicin and paclitaxel) bounded to the polymer via acid liable linkers and pH-sensitive copolymeric nanocarriers prepared by block copolymers containing polymer blocks linked with acid-cleavable groups. Besides, advanced platforms in biomedicine for special biotherapeutic molecules delivery were reviewed in the article. Furthermore, several acid-sensitive linkages were reviewed to study the mechanism of the controlled pH-responsive drug delivery, such as hydrazone, acetal, cis-aconityl linker and ?-thioether ester, as well as improvement of drug pharmacokinetics.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE