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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.1 P.29-34

http://doi.org/10.1631/jzus.B1100078


Early effects of oral administration of omeprazole and roxatidine on intragastric pH


Author(s):  Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori

Affiliation(s):  Gastroenterology Division, Yokohama City University School of Medicine, Yokohama 236-0004, Japan, Department of Medical Education, Yokohama City University School of Medicine, Yokohama 236-0004, Japan, Office of Postgraduate Medical Education, Yokohama City University Hospital, Yokohama 236-0004, Japan

Corresponding email(s):   inamorim@med.yokohama-cu.ac.jp

Key Words:  Proton pump inhibitor, H2-receptor antagonist, Intragastric pH, Omeprazole, Roxatidine


Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori. Early effects of oral administration of omeprazole and roxatidine on intragastric pH[J]. Journal of Zhejiang University Science B, 2012, 13(1): 29-34.

@article{title="Early effects of oral administration of omeprazole and roxatidine on intragastric pH",
author="Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori",
journal="Journal of Zhejiang University Science B",
volume="13",
number="1",
pages="29-34",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100078"
}

%0 Journal Article
%T Early effects of oral administration of omeprazole and roxatidine on intragastric pH
%A Hiroshi Iida
%A Shingo Kato
%A Yusuke Sekino
%A Eiji Sakai
%A Takashi Uchiyama
%A Hiroki Endo
%A Kunihiro Hosono
%A Yasunari Sakamoto
%A Koji Fujita
%A Masato Yoneda
%A Tomoko Koide
%A Hirokazu Takahashi
%A Chikako Tokoro
%A Ayumu Goto
%A Yasunobu Abe
%A Noritoshi Kobayashi
%A Kensuke Kubota
%A Eiji Gotoh
%A Shin Maeda
%A Atsushi Nakajima
%A Masahiko Inamori
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 1
%P 29-34
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100078

TY - JOUR
T1 - Early effects of oral administration of omeprazole and roxatidine on intragastric pH
A1 - Hiroshi Iida
A1 - Shingo Kato
A1 - Yusuke Sekino
A1 - Eiji Sakai
A1 - Takashi Uchiyama
A1 - Hiroki Endo
A1 - Kunihiro Hosono
A1 - Yasunari Sakamoto
A1 - Koji Fujita
A1 - Masato Yoneda
A1 - Tomoko Koide
A1 - Hirokazu Takahashi
A1 - Chikako Tokoro
A1 - Ayumu Goto
A1 - Yasunobu Abe
A1 - Noritoshi Kobayashi
A1 - Kensuke Kubota
A1 - Eiji Gotoh
A1 - Shin Maeda
A1 - Atsushi Nakajima
A1 - Masahiko Inamori
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 1
SP - 29
EP - 34
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100078


Abstract: 
Objective: The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an h2-receptor antagonist, roxatidine 75 mg. Methods: Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period. Results: During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively). Conclusions: In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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