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Bio-Design and Manufacturing  2021 Vol.4 No.3 P.526-540

http://doi.org/10.1007/s42242-021-00134-7


3D tumor model biofabrication


Author(s):  Xi Zeng, Zhiguang Guo & Weimin Liu

Affiliation(s):  Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, State University of New York (SUNY), PO Box 6000, Binghamton, NY 13902, USA

Corresponding email(s):   kye@binghamton.edu

Key Words:  Tumor models, Biofabrication, Tumor spheroids, Microfluidic devices, 3D bioprinting


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Xi Zeng, Zhiguang Guo & Weimin Liu. 3D tumor model biofabrication[J]. Journal of Zhejiang University Science D, 2021, 4(3): 526-540.

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author="Xi Zeng, Zhiguang Guo & Weimin Liu",
journal="Journal of Zhejiang University Science D",
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year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00134-7"
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Abstract: 
Animal models have been extensively used in cancer pathology studies and drug discovery. These models, however, fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions. Three-dimensional (3D) cancer models present an alternative to automated high-throughput cancer drug discovery and oncology. In this review, we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment. We discussed various biofabrication technologies, including 3D bioprinting techniques developed for characterizing tumor progression, metastasis, and response to treatment.

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