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On-line Access: 2021-05-04
Received: 2020-10-24
Revision Accepted: 2021-04-05
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3D tumor model biofabrication
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Xi Zeng, Zhiguang Guo & Weimin Liu. 3D tumor model biofabrication[J]. Journal of Zhejiang University Science D, 2021, 4(3): 526-540.
@article{title="3D tumor model biofabrication",
author="Xi Zeng, Zhiguang Guo & Weimin Liu",
journal="Journal of Zhejiang University Science D",
volume="4",
number="3",
pages="526-540",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00134-7"
}
%0 Journal Article
%T 3D tumor model biofabrication
%A Xi Zeng
%A Zhiguang Guo & Weimin Liu
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 3
%P 526-540
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00134-7
TY - JOUR
T1 - 3D tumor model biofabrication
A1 - Xi Zeng
A1 - Zhiguang Guo & Weimin Liu
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 3
SP - 526
EP - 540
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00134-7
Abstract: Animal models have been extensively used in cancer pathology studies and drug discovery. These models, however, fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions. Three-dimensional (3D) cancer models present an alternative to automated high-throughput cancer drug discovery and oncology. In this review, we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment. We discussed various biofabrication technologies, including 3D bioprinting techniques developed for characterizing tumor progression, metastasis, and response to treatment.
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