CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 0
Clicked: 592
Huaixu Li,Yang Qiao,Xingliang Dai,Haotian Tian,Zhenyu Han,Sheng Cheng,Peng Gao,Hongwei Cheng. 3D Bioprinting Tumor Models and their Application Progress[J]. Journal of Zhejiang University Science , , (): .
@article{title="3D Bioprinting Tumor Models and their Application Progress",
author="Huaixu Li,Yang Qiao,Xingliang Dai,Haotian Tian,Zhenyu Han,Sheng Cheng,Peng Gao,Hongwei Cheng",
journal="Journal of Zhejiang University Science ",
volume="",
number="",
pages="",
year="",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-BDMJ-D-23-00285"
}
%0 Journal Article
%T 3D Bioprinting Tumor Models and their Application Progress
%A Huaixu Li
%A Yang Qiao
%A Xingliang Dai
%A Haotian Tian
%A Zhenyu Han
%A Sheng Cheng
%A Peng Gao
%A Hongwei Cheng
%J Journal of Zhejiang University SCIENCE
%V
%N
%P
%@ 1673-1581
%D
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-BDMJ-D-23-00285
TY - JOUR
T1 - 3D Bioprinting Tumor Models and their Application Progress
A1 - Huaixu Li
A1 - Yang Qiao
A1 - Xingliang Dai
A1 - Haotian Tian
A1 - Zhenyu Han
A1 - Sheng Cheng
A1 - Peng Gao
A1 - Hongwei Cheng
J0 - Journal of Zhejiang University Science
VL -
IS -
SP -
EP -
%@ 1673-1581
Y1 -
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-BDMJ-D-23-00285
Abstract: The most common cause of mortality in people is cancer, which has turned into an
unbridgeable health gap because of its unrestrained aberrant proliferation, quick growth,
metastasis, and high heterogeneity. Conventional two-dimensional cell culture models
along with animal models for tumor diagnostic and therapeutic studies have extremely
low clinical translation rates due to their intrinsic limitations. Appropriate tumor models
are required for cancer research. Engineered human 3D cancer models are better able
to replicate the spatial organization, cellular resources, and tumor microenvironment
features (hypoxia, necrosis, and delayed proliferation) of the actual human tumor
microenvironment. Emerging technology known as 3D bioprinting makes it possible to
fabricate live structures by precisely regulating the spatial distribution of cells,
biomolecules, and matrix components. The aim of this paper is to review the current
technology and bioink of 3D bioprinted cancer models, including glioma, breast, liver,
intestinal, cervical, ovarian, and neuroblastoma models, as well as the advances in their
applications in the fields of tumor microenvironment, tumor vascularization, tumor
stem cells, tumor resistance and drug screening, tumor immunotherapy, and precision
medicine.
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