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Bio-Design and Manufacturing  2021 Vol.4 No.3 P.526-540

http://doi.org/10.1007/s42242-021-00134-7


3D tumor model biofabrication


Author(s):  Xi Zeng, Zhiguang Guo & Weimin Liu

Affiliation(s):  Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, State University of New York (SUNY), PO Box 6000, Binghamton, NY 13902, USA

Corresponding email(s):   kye@binghamton.edu

Key Words:  Tumor models, Biofabrication, Tumor spheroids, Microfluidic devices, 3D bioprinting


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Xi Zeng, Zhiguang Guo & Weimin Liu. 3D tumor model biofabrication[J]. Journal of Zhejiang University Science D, 2021, 4(3): 526-540.

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Abstract: 
Animal models have been extensively used in cancer pathology studies and drug discovery. These models, however, fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions. Three-dimensional (3D) cancer models present an alternative to automated high-throughput cancer drug discovery and oncology. In this review, we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment. We discussed various biofabrication technologies, including 3D bioprinting techniques developed for characterizing tumor progression, metastasis, and response to treatment.

美国宾汉顿大学Kaiming Ye等 | 三维肿瘤模型生物制造

本综述论文聚焦三维肿瘤模型的制造技术。动物模型已被广泛应用于癌症病理学研究和药物研发。然而,这些模型未能很好地反映复杂的人类肿瘤微环境,并且难以在更接近人类的生理条件下进行高通量药物筛选。三维(3D)癌症模型提供了自动化高通量癌症药物发现和肿瘤学的替代方案。本文重点介绍了最近在构建3D肿瘤模型方面的技术创新;这些模型模拟了复杂的人类肿瘤微环境以及患者对治疗的反应。讨论了各种生物制造技术,包括为表征肿瘤进展、转移和对治疗的反应而开发的3D生物打印技术。

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