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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.201-209

http://doi.org/10.1007/s42242-021-00156-1


Epidermal self-powered sweat sensors for glucose and lactate monitoring


Author(s):  Xingcan Huang, Jiyu Li, Yiming Liu, Tszhung Wong, Jingyou Su, Kuanming Yao, Jingkun Zhou, Ya Huang, Hu Li, Dengfeng Li, Mengge Wu, Enming Song, Shijiao Han & Xinge Yu

Affiliation(s):  Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China; more

Corresponding email(s):   xingeyu@cityu.edu.hk

Key Words:  Sweat sensor, Self-powered, Epidermal electronics, Enzymatic biofuel cells, Microfluidics


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Xingcan Huang, Jiyu Li, Yiming Liu, Tszhung Wong, Jingyou Su, Kuanming Yao, Jingkun Zhou, Ya Huang, Hu Li, Dengfeng Li, Mengge Wu, Enming Song, Shijiao Han & Xinge Yu. Epidermal self-powered sweat sensors for glucose and lactate monitoring[J]. Journal of Zhejiang University Science D, 2022, 5(1): 201-209.

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author="Xingcan Huang, Jiyu Li, Yiming Liu, Tszhung Wong, Jingyou Su, Kuanming Yao, Jingkun Zhou, Ya Huang, Hu Li, Dengfeng Li, Mengge Wu, Enming Song, Shijiao Han & Xinge Yu",
journal="Journal of Zhejiang University Science D",
volume="5",
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pages="201-209",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00156-1"
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%A Kuanming Yao
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A1 - Jingkun Zhou
A1 - Ya Huang
A1 - Hu Li
A1 - Dengfeng Li
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Abstract: 
Sweat could be a carrier of informative biomarkers for health status identification; therefore, wearable sweat sensors have attracted significant attention for research. An external power source is an important component of wearable sensors, however, the current power supplies, i.e., batteries, limit further shrinking down the size of these devices and thus limit their application areas and scenarios. Herein, we report a stretchable self-powered biosensor with epidermal electronic format that enables the in situ detection of lactate and glucose concentration in sweat. enzymatic biofuel cells serve as self-powered sensing modules allowing the sweat sensor to exhibit a determination coefficient (R2) of 0.98 with a sensitivity of 2.48 mV/mM for lactate detection, and R2 of 0.96 with a sensitivity of 0.11 mV/?M for glucose detection. The microfluidic channels developed in an ultra-thin soft flexible polydimethylsiloxane layer not only enable the effective collection of sweat, but also provide excellent mechanical properties with stable performance output even under 30% stretching. The presented soft sweat sensors can be integrated at nearly any location of the body for the continuous monitoring of lactate and glucose changes during normal daily activities such as exercise. Our results provide a promising approach to develop next-generation sweat sensors for real-time and in situ sweat analysis.

香港城市大学于欣格等 | 用于监测汗液葡萄糖和乳酸的自供电的电子皮肤

本研究论文聚焦用于监测汗液葡萄糖和乳酸的自供电的电子皮肤研究。汗液中包含人体多种分泌物,分泌物浓度可以直接反映身体健康状况。因此,近年来可穿戴汗液传感器的研究引起了极大的关注。然而,作为可穿戴传感器目前最主要的供电方式,电池的嵌入限制了器件尺寸的进一步缩小,从而限制了其应用场景和领域。因此,我们提出一种基于皮肤电子的可拉伸的自供电生物传感器,能够在皮肤上实时监控汗液中的乳酸和葡萄糖浓度。该自供电汗液传感器检测乳酸时的决定系数(R2)能够达到0.98,灵敏度为2.48 mV/mM;检测葡萄糖的决定系数达到0.96,灵敏度为0.11 mV/μM。通过结合自主设计的微流道系统和力学结构,在超薄柔软的聚二甲基硅氧烷(PDMS)基底上,该电子皮肤不仅能够有效地收集汗液,而且展现了良好的机械性能,即使拉伸30%的情况下也能有稳定的性能输出。该用于监控汗液葡萄糖和乳酸的自供电的电子皮肤几乎可以贴附在身体的任何位置,可以用于连续监测日常运动中的乳酸和葡萄糖变化。我们的成果为开发下一代用于实时汗液分析的传感器提供了一种新的可行性方案。

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