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Bio-Design and Manufacturing  2024 Vol.7 No.1 P.14-30

http://doi.org/10.1007/s42242-023-00246-2


Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species


Author(s):  Xinshuo Huang, Baoming Liang, Shantao Zheng, Feifei Wu, Mengyi He, Shuang Huang, Jingbo Yang, Qiangqiang Ouyang, Fanmao Liu, Jing Liu, Hui-jiuan Chen & Xi Xie

Affiliation(s):  State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou 510006, China; more

Corresponding email(s):   chenhuix5@mail.sysu.edu.cn, xiexi27@mail.sysu.edu.cn

Key Words:  Microarrow sensor array, glucose sensing, reactive oxygen species sensing, integrated system, continuous monitoring


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Xinshuo Huang, Baoming Liang, Shantao Zheng, Feifei Wu, Mengyi He, Shuang Huang, Jingbo Yang, Qiangqiang Ouyang, Fanmao Liu, Jing Liu, Hui-jiuan Chen & Xi Xie . Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species[J]. Journal of Zhejiang University Science D, 2024, 7(1): 14-30.

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author="Xinshuo Huang, Baoming Liang, Shantao Zheng, Feifei Wu, Mengyi He, Shuang Huang, Jingbo Yang, Qiangqiang Ouyang, Fanmao Liu, Jing Liu, Hui-jiuan Chen & Xi Xie ",
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%A Xinshuo Huang
%A Baoming Liang
%A Shantao Zheng
%A Feifei Wu
%A Mengyi He
%A Shuang Huang
%A Jingbo Yang
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%A Fanmao Liu
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A1 - Shuang Huang
A1 - Jingbo Yang
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Abstract: 
Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo. Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation, and the presence of reactive oxygen species (ROS) due to inflammation may affect glucose detection. Microneedle technology is less invasive, yet microneedle adhesion with skin tissue is limited. In this work, we developed a microarrow sensor array (MASA), which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H2O2 (representative of ROS) in interstitial fluid in vivo. The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional (3D) microneedle array. Due to the arrow tip mechanically interlocking with the tissue, the microarrow array could better adhere to the skin surface after penetration into skin. The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H2O2 concentrations, with the detection of H2O2 providing a valuable reference for assessing the inflammation state. Finally, the MASA was integrated into a monitoring system using custom circuitry. This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

中山大学谢曦等 | 具有皮肤黏附性能的微箭头传感阵列,用于实现活体皮下葡萄糖与活性氧的连续同步监测

本研究论文围绕葡萄糖检测应用中微环境活性物质干扰、检测电极对皮肤组织贴附性不足等难题,通过激光微细加工技术设计并制备了带有箭头结构的微针电极。通过对贵金属保护层、电化学酶传感层与高分子限制层的修饰方法进行改进,分别开发了面向葡萄糖与活性氧检测应用的箭头微针传感电极,实现了对不同浓度的葡萄糖和H2O2高灵敏度、宽响应范围与良好重现性的特异性响应。基于降维加工集成技术开发了基于箭头微针的动态血糖/活性氧同步传感三维阵列(MASA),并验证箭头微针结构对组织粘附性与活体传感稳定性的提升。所设计的微箭头结构基于机械连锁作用与活体组织间的稳固连接,避免了化学粘合剂的潜在炎症反应,以提高传感器件与皮肤间信号通路的稳定性。进一步在活体动物上验证所开发器件的对活体皮下血糖和H2O2浓度的同步、连续监测性能,并基于H2O2检测结果辅助判定组织液中的炎症发生程度,评估葡萄糖检测结果受微环境活性物质干扰水平。最后,本论文设计并开发了一套可穿戴式的嵌入式电路,将微针传感阵列集成为箭头微针动态血糖/活性氧同步传感系统。文章的工作有利于解决活体检测中易受内源电活性物质干扰以及与皮肤组织的贴附性弱的问题,有望为糖尿病患者血糖波动的持续稳定监测提供辅助工具。

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