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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.6-8

http://doi.org/10.1007/s42242-021-00166-z


Industry news: the additive manufacturing of nerve conduits for the treatment of peripheral nerve injury


Author(s):  Ying Han, Jun Yin

Affiliation(s):  The State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310028, China; more

Corresponding email(s):   junyin@zju.edu.cn

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Ying Han, Jun Yin. Industry news: the additive manufacturing of nerve conduits for the treatment of peripheral nerve injury[J]. Journal of Zhejiang University Science D, 2022, 5(1): 6-8.

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Abstract: 

浙江大学尹俊等 | 增材制造神经导管用于外周神损伤修复

本社论聚焦3D打印神经导管在外周神经再生治疗中的应用。外周神经损伤在生产生活中十分常见,针对大段神经缺损,神经导管可以提供一个利于神经恢复的封闭微环境,其结构设计和制造方法得到了广泛研究。现阶段对于导管内部微环境的仿生设计,主要是引入物理引导地形和生化诱导因子,如微结构定向、多层设计、生长因子缓释等,这些设计的实现需要依托高精度、可定制化的制造技术。而3D打印增材制造技术可以精准高效地实现生物材料、生化因子甚至活细胞的空间定点分布,使其在神经导管的制备中具备独特优势,其中挤出、光固化、喷墨3D打印技术应用最广。本文从具体案例出发,分析了几种3D打印技术应用于神经导管制备的优势和不足,涵盖了陈绍琛、苟马玲、Michael C. McAlpine等课题组的工作,同时聚焦该领域目前的研究趋势,探讨了多材料复合神经导管的研究前景,对工业生产提供指导作用。

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