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On-line Access: 2022-03-24

Received: 2021-09-01

Revision Accepted: 2022-02-06

Crosschecked: 2022-03-24

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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.451-464

http://doi.org/10.1007/s42242-022-00190-7


Customizable design of multiple-biomolecule delivery platform for enhanced osteogenic responses via tailored assembly system


Author(s):  Hyun Lee, Min-Kyu Lee, Ginam Han, Hyoun-Ee Kim, Juha Song, Yuhyeon Na, Chang-Bun Yoon, SeKwon Oh, Tae-Sik Jang & Hyun-Do Jung

Affiliation(s):  Department of Biomedical-Chemical Engineering, Catholic University of Korea, Bucheon 14662, Republic of Korea ; more

Corresponding email(s):   tsjang@chosun.ac.kr, hdjung@catholic.ac.kr

Key Words:  Functionally graded porous titanium scaffold, Tailored assembly system, Tailored assembly system, Multiple-biomolecule delivery, Bone tissue engineering


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Hyun Lee, Min-Kyu Lee, Ginam Han, Hyoun-Ee Kim, Juha Song, Yuhyeon Na, Chang-Bun Yoon, SeKwon Oh, Tae-Sik Jang & Hyun-Do Jung. Customizable design of multiple-biomolecule delivery platform for enhanced osteogenic responses via tailored assembly system[J]. Journal of Zhejiang University Science D, 2022, 5(3): 451-464.

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Abstract: 
Porous titanium (Ti) scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties. However, naturally formed TiO2 on the surface limits fast osseointegration. Different biomolecules have been widely utilized to overcome this issue; however, homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release behaviors. In this study, functionally graded porous Ti scaffolds (FGPTs) with dense inner and porous outer parts were fabricated using a two-body combination and densification procedure. FGPTs with growth factor (BMP-2) and antibiotics (TCH) exhibited suitable mechanical properties as bone substituting material and presented good structural stability. The release of BMP-2 was considerably prolonged, whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds (control group). The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of BMP-2. The antimicrobial properties of these scaffolds were verified using S. aureus in terms of prior release time. In addition, various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

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