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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Bioprinted integrated gradient biomechanical signal-tailored osteosarcoma model: advancing insights into tumor development and drug screening
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Abstract: In current osteosarcoma research and drug screening, in vitro 3D models are favored
for overcoming the limitations of traditional models. In in vitro 3D models, tumor
microenvironment simulation, especially mechanical microenvironment, is crucial for
tumor biological effects. However, current in vitro tumor model construction for
osteosarcoma is often limited to a single mechanical signal, which fails to simulate the
diversity of osteosarcoma mechanical stimuli. In this study, we utilized embedded
bioprinting technology and multiple response properties of calcium ions in soft stiffness
systems, hard stiffness systems, and osteosarcoma cell biological functions to construct
an integrated gradient biomechanical signal-tailored osteosarcoma model. Specifically,
we achieved this by printing a fibrinogen bioink containing calcium ions and
osteosarcoma tumor spheroids within an extracellular matrix composed of
methacryloylated alginate, methacryloylated gelatin, and thrombin, which is rich in
polysaccharides and proteins and exhibits self-healing properties. In vitro and in vivo
studies showed that the integrated gradient biomechanical signal-tailored osteosarcoma
model enhanced tumor stemness, proliferation and migration, successfully reproduced
the nest-like structure of cancer, and provided an in vitro research platform closer to a
natural tumor. In conclusion, this study proposes a novel integrated gradient
biomechanical signal-tailored osteosarcoma model construction system that provides a
new strategy for the clinical understanding of tumor development, drug screening, and
exploration of drug resistance and metastasis mechanisms.
Xuelian Mi, Ya Ren, Hanbo Wang, Lei Qiang, Weiqing Kong, Hui Wang, Xue Yang, Yihao Liu, Han Yang, Di Xiao, Zhenjiang Ma, Guoxing Xu, Changru Zhang, Jinwu Wang. Bioprinted integrated gradient biomechanical signal-tailored osteosarcoma model: advancing insights into tumor development and drug screening[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Bioprinted integrated gradient biomechanical signal-tailored osteosarcoma model:
advancing insights into tumor development and drug screening",
author="Xuelian Mi, Ya Ren, Hanbo Wang, Lei Qiang, Weiqing Kong, Hui Wang, Xue Yang, Yihao Liu, Han Yang, Di Xiao, Zhenjiang Ma, Guoxing Xu, Changru Zhang, Jinwu Wang",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400108"
}
%0 Journal Article
%T Bioprinted integrated gradient biomechanical signal-tailored osteosarcoma model:
advancing insights into tumor development and drug screening
%A Xuelian Mi
%A Ya Ren
%A Hanbo Wang
%A Lei Qiang
%A Weiqing Kong
%A Hui Wang
%A Xue Yang
%A Yihao Liu
%A Han Yang
%A Di Xiao
%A Zhenjiang Ma
%A Guoxing Xu
%A Changru Zhang
%A Jinwu Wang
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400108
TY - JOUR
T1 - Bioprinted integrated gradient biomechanical signal-tailored osteosarcoma model:
advancing insights into tumor development and drug screening
A1 - Xuelian Mi
A1 - Ya Ren
A1 - Hanbo Wang
A1 - Lei Qiang
A1 - Weiqing Kong
A1 - Hui Wang
A1 - Xue Yang
A1 - Yihao Liu
A1 - Han Yang
A1 - Di Xiao
A1 - Zhenjiang Ma
A1 - Guoxing Xu
A1 - Changru Zhang
A1 - Jinwu Wang
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400108
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