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On-line Access: 2025-05-20
Received: 2024-05-05
Revision Accepted: 2024-09-21
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Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke
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Meili Zhang (张媚丽), Taojian Fan (范涛健), Shujiang Yin (殷淑江), Jie Li (李洁), Jing Hou (侯靓), Ke Zhang (张珂), Bo Han (韩博), Wen Chen (陈文), Han Zhang (张晗) & Xing Tian (田星) . Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke[J]. Journal of Zhejiang University Science D, 2025, 8(3): 391–409.
@article{title="Polypeptide-modified black phosphorus nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke",
author="Meili Zhang (张媚丽), Taojian Fan (范涛健), Shujiang Yin (殷淑江), Jie Li (李洁), Jing Hou (侯靓), Ke Zhang (张珂), Bo Han (韩博), Wen Chen (陈文), Han Zhang (张晗) & Xing Tian (田星) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="3",
pages="391–409",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400176"
}
%0 Journal Article
%T Polypeptide-modified black phosphorus nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke
%A Meili Zhang (张媚丽)
%A Taojian Fan (范涛健)
%A Shujiang Yin (殷淑江)
%A Jie Li (李洁)
%A Jing Hou (侯靓)
%A Ke Zhang (张珂)
%A Bo Han (韩博)
%A Wen Chen (陈文)
%A Han Zhang (张晗) & Xing Tian (田星)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 3
%P 391–409
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400176
TY - JOUR
T1 - Polypeptide-modified black phosphorus nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke
A1 - Meili Zhang (张媚丽)
A1 - Taojian Fan (范涛健)
A1 - Shujiang Yin (殷淑江)
A1 - Jie Li (李洁)
A1 - Jing Hou (侯靓)
A1 - Ke Zhang (张珂)
A1 - Bo Han (韩博)
A1 - Wen Chen (陈文)
A1 - Han Zhang (张晗) & Xing Tian (田星)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 3
SP - 391–409
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400176
Abstract: Ischemic stroke is the leading cause of death in China, accounting for approximately one-third of all stroke-associated deaths
worldwide. Currently, thrombolysis is employed for ischemic strokes. However, due to the limited therapeutic window of
thrombolytic agents, most patients do not receive the drug at the right time. Moreover, these agents are associated with risks
of hemorrhage and reperfusion damage. Herein, Angiopep-2 (ANG)-black phosphorus (BP)-resveratrol (RES), a drug-loaded
system, was used to deliver drugs across the blood–brain barrier (BBB). ANG-BP-RES has a uniform size, stable structure,
good photothermal effect, and strong drug release ability under near-infrared (NIR) irradiation and acidic conditions. Further
more, ANG-BP-RES can efficiently target the brain and improve BBB permeability, exerting a significant therapeutic effect
against ischemic brain injury, especially after NIR irradiation. ANG-BP-RES is also biocompatible and shows minimal toxic
ity toward cells and tissues. This study offers novel insights into the therapeutic management of ischemic brain injury.
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