CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2024-10-18
Cited: 0
Clicked: 659
Citations: Bibtex RefMan EndNote GB/T7714
https://orcid.org/0000-0002-1350-2961
Yuyi ZHENG, Xiaojie CHEN, Yi WANG, Zhong CHEN, Di WU. Phenolic-enabled nanotechnology: a new strategy for central nervous system disease therapy[J]. Journal of Zhejiang University Science B, 2024, 25(10): 890-913.
@article{title="Phenolic-enabled nanotechnology: a new strategy for central nervous system disease therapy",
author="Yuyi ZHENG, Xiaojie CHEN, Yi WANG, Zhong CHEN, Di WU",
journal="Journal of Zhejiang University Science B",
volume="25",
number="10",
pages="890-913",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300839"
}
%0 Journal Article
%T Phenolic-enabled nanotechnology: a new strategy for central nervous system disease therapy
%A Yuyi ZHENG
%A Xiaojie CHEN
%A Yi WANG
%A Zhong CHEN
%A Di WU
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 10
%P 890-913
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300839
TY - JOUR
T1 - Phenolic-enabled nanotechnology: a new strategy for central nervous system disease therapy
A1 - Yuyi ZHENG
A1 - Xiaojie CHEN
A1 - Yi WANG
A1 - Zhong CHEN
A1 - Di WU
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 10
SP - 890
EP - 913
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300839
Abstract: Polyphenolic compounds have received tremendous attention in biomedicine because of their good biocompatibility and unique physicochemical properties. In recent years, phenolic-enabled nanotechnology (PEN) has become a hotspot of research in the medical field, and many promising studies have been reported, especially in the application of central nervous system (CNS) diseases. Polyphenolic compounds have superior anti-inflammatory and antioxidant properties, and can easily cross the blood‒brain barrier, as well as protect the nervous system from metabolic damage and promote learning and cognitive functions. However, although great advances have been made in this field, a comprehensive review regarding PEN-based nanomaterials for CNS therapy is lacking. A systematic summary of the basic mechanisms and synthetic strategies of PEN-based nanomaterials is beneficial for meeting the demand for the further development of novel treatments for CNS diseases. This review systematically introduces the fundamental physicochemical properties of PEN-based nanomaterials and their applications in the treatment of CNS diseases. We first describe the different ways in which polyphenols interact with other substances to form high-quality products with controlled sizes, shapes, compositions, and surface chemistry and functions. The application of PEN-based nanomaterials in the treatment of CNS diseases is then described, which provides a reference for subsequent research on the treatment of CNS diseases.
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