Similar articles

Abstract: Polyphenolic compounds have received tremendous attention in biomedicine due to their good biocompatibility and unique physicochemical properties. In recent years, phenolic-enabled nanotechnology (PEN) has become a hotspot of research in the medical field, and many promising studies have been reported, especially in the application of central nervous system (CNS) diseases. Its superior properties include being anti-inflammatory, antioxidant, and easily crossing the blood–brain barrier, as well as protecting the nervous system from metabolic damage and promoting learning and cognitive functions. However, although great advances have been made in this field, a comprehensive review regarding PEN-enabled CNS therapy is lacking. A systematic summary of the basic mechanisms and synthetic strategies of PEN is beneficial for meeting the demand for the further development of novel treatments for CNS diseases. This review will systematically introduce the fundamental physicochemical properties of PEN materials and their applications in the treatment of CNS diseases. We first describe the different ways in which polyphenols interact with other substances to form high-quality products with controlled size, shape, composition, and surface chemistry and function. The application of PEN in the treatment of CNS diseases is then described, which provides a reference for subsequent research into the treatment of CNS diseases.