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On-line Access: 2025-05-20
Received: 2024-08-22
Revision Accepted: 2024-10-29
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Composite poly(lactic-co-glycolic acid) and a decellularized extracellular matrix conduit with Schwann cells for enhanced nerve regeneration
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Zhifa Xue (薛志发), Yuye Huang (黄瑜烨), De Bi (毕得), Kai Ye (叶开), Hangyu Zhou (周航宇), Lizhe He (贺立喆), Peng Wei (魏鹏) & Yangjian Wang (王扬剑). Composite poly(lactic-co-glycolic acid) and a decellularized extracellular matrix conduit with Schwann cells for enhanced nerve regeneration[J]. Journal of Zhejiang University Science D, 2025, 8(3): 359–374.
@article{title="Composite poly(lactic-co-glycolic acid) and a decellularized extracellular
matrix conduit with Schwann cells for enhanced nerve regeneration",
author="Zhifa Xue (薛志发), Yuye Huang (黄瑜烨), De Bi (毕得), Kai Ye (叶开), Hangyu Zhou (周航宇), Lizhe He (贺立喆), Peng Wei (魏鹏) & Yangjian Wang (王扬剑)",
journal="Journal of Zhejiang University Science D",
volume="8",
number="3",
pages="359–374",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400334"
}
%0 Journal Article
%T Composite poly(lactic-co-glycolic acid) and a decellularized extracellular
matrix conduit with Schwann cells for enhanced nerve regeneration
%A Zhifa Xue (薛志发)
%A Yuye Huang (黄瑜烨)
%A De Bi (毕得)
%A Kai Ye (叶开)
%A Hangyu Zhou (周航宇)
%A Lizhe He (贺立喆)
%A Peng Wei (魏鹏) & Yangjian Wang (王扬剑)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 3
%P 359–374
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400334
TY - JOUR
T1 - Composite poly(lactic-co-glycolic acid) and a decellularized extracellular
matrix conduit with Schwann cells for enhanced nerve regeneration
A1 - Zhifa Xue (薛志发)
A1 - Yuye Huang (黄瑜烨)
A1 - De Bi (毕得)
A1 - Kai Ye (叶开)
A1 - Hangyu Zhou (周航宇)
A1 - Lizhe He (贺立喆)
A1 - Peng Wei (魏鹏) & Yangjian Wang (王扬剑)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 3
SP - 359–374
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400334
Abstract: Peripheral nerve injuries (PNIs) affect approximately one million people globally every year. While autologous nerve trans
plantation remains the gold standard for healing PNIs with large gaps, limitations such as donor site morbidity and limited
nerve availability present challenges in clinical application, highlighting the need for innovative solutions based on synthetic
biomaterials. In this study, we explored a composite nerve conduit that combines a poly(lactic-co-glycolic acid) (PLGA)
shell and a decellularized extracellular matrix (dECM) seeded with Schwann cells (SCs). In particular, the dECM, derived
from rat sciatic nerves, retains the native tissue structure and bioactive components. In vitro studies showed that SC-seeded
dECM promotes cell viability, proliferation, and alignment. In vivo testing using a rat sciatic nerve defect model demon
strated that the PLGA/dECM-SC conduit significantly improved nerve regeneration compared with conduits without SCs,
showing enhanced axonal growth, myelination, and motor function restoration comparable to autografts. This approach of
fers a promising alternative to autologous nerve grafts in the clinical treatment of PNIs.
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