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On-line Access: 2025-11-26
Received: 2024-12-17
Revision Accepted: 2025-03-18
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Research insights and clinical opportunities of functional organoid-based platforms
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Yueyu Huang (黄月雨), Wenhui Shen (沈文辉), Kehan Li (李可涵), Yutian Zhang (张雨恬), Qiaoli Lv (吕巧莉), Changchun Wang (王长春), Weimin Mao (毛伟敏) & An Zhao (赵安) . Research insights and clinical opportunities of functional organoid-based platforms[J]. Journal of Zhejiang University Science D, 2025, 8(6): 1063-1079.
@article{title="Research insights and clinical opportunities of functional organoid-based platforms",
author="Yueyu Huang (黄月雨), Wenhui Shen (沈文辉), Kehan Li (李可涵), Yutian Zhang (张雨恬), Qiaoli Lv (吕巧莉), Changchun Wang (王长春), Weimin Mao (毛伟敏) & An Zhao (赵安) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="6",
pages="1063-1079",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400519"
}
%0 Journal Article
%T Research insights and clinical opportunities of functional organoid-based platforms
%A Yueyu Huang (黄月雨)
%A Wenhui Shen (沈文辉)
%A Kehan Li (李可涵)
%A Yutian Zhang (张雨恬)
%A Qiaoli Lv (吕巧莉)
%A Changchun Wang (王长春)
%A Weimin Mao (毛伟敏) & An Zhao (赵安)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 6
%P 1063-1079
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400519
TY - JOUR
T1 - Research insights and clinical opportunities of functional organoid-based platforms
A1 - Yueyu Huang (黄月雨)
A1 - Wenhui Shen (沈文辉)
A1 - Kehan Li (李可涵)
A1 - Yutian Zhang (张雨恬)
A1 - Qiaoli Lv (吕巧莉)
A1 - Changchun Wang (王长春)
A1 - Weimin Mao (毛伟敏) & An Zhao (赵安)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 6
SP - 1063
EP - 1079
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400519
Abstract: Stem cell- or tissue-derived three-dimensional organ-like formations, known as organoids, are emerging as effective tools in
biomedicine. Since they may be useful in developing customized therapeutic solutions and efficient drug screening proto
cols, organoids can deepen our understanding of novel disease mechanisms. In doing so, they can facilitate advancements in
drug discovery platforms, pharmacological safety, and clinical trials. This review explores various biomedical applications of
organoids, including drug development and disease modeling, and highlights specific tools and analytical techniques that can
be employed to investigate organoids and their microenvironments. Finally, we review recent clinical trials and patents re
lated to organoids that show great promise for future clinical translation.
Open peer comments: Debate/Discuss/Question/Opinion
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