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On-line Access: 2025-11-26
Received: 2025-02-07
Revision Accepted: 2025-05-01
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Polymeric micelles: “magic bullets” for cancer treatment
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Yue Gao (高悦), Meihong Zhang (张美红), Qian Chen (陈倩), Yuxin Lin (蔺语欣), Chuanbin Wu (吴传斌), Xin Pan (潘昕), Ling Guo (郭羚), Tze Ning Hiew & Zhengwei Huang (黄郑炜) . Polymeric micelles: “magic bullets” for cancer treatment[J]. Journal of Zhejiang University Science D, 2025, 8(6): 1103-1125.
@article{title="Polymeric micelles: “magic bullets” for cancer treatment",
author="Yue Gao (高悦), Meihong Zhang (张美红), Qian Chen (陈倩), Yuxin Lin (蔺语欣), Chuanbin Wu (吴传斌), Xin Pan (潘昕), Ling Guo (郭羚), Tze Ning Hiew & Zhengwei Huang (黄郑炜) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="6",
pages="1103-1125",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500054"
}
%0 Journal Article
%T Polymeric micelles: “magic bullets” for cancer treatment
%A Yue Gao (高悦)
%A Meihong Zhang (张美红)
%A Qian Chen (陈倩)
%A Yuxin Lin (蔺语欣)
%A Chuanbin Wu (吴传斌)
%A Xin Pan (潘昕)
%A Ling Guo (郭羚)
%A Tze Ning Hiew & Zhengwei Huang (黄郑炜)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 6
%P 1103-1125
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500054
TY - JOUR
T1 - Polymeric micelles: “magic bullets” for cancer treatment
A1 - Yue Gao (高悦)
A1 - Meihong Zhang (张美红)
A1 - Qian Chen (陈倩)
A1 - Yuxin Lin (蔺语欣)
A1 - Chuanbin Wu (吴传斌)
A1 - Xin Pan (潘昕)
A1 - Ling Guo (郭羚)
A1 - Tze Ning Hiew & Zhengwei Huang (黄郑炜)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 6
SP - 1103
EP - 1125
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500054
Abstract: Nanocarriers are an efficient drug delivery tool used for cancer treatment. Among various nanocarriers, polymeric micelles (PMs) have garnered attention in recent years due to their excellent properties, including improved solubility of insoluble drugs, enhanced targeting and accumulation of drugs at the cancer site, increased sensitivity of cancer cells to chemotherapeutic drugs, and prolonged circulation time. This review summarizes the preparation methods, characterization, advantages, and classification of PMs as drug delivery systems for oncology therapeutics. In particular, the self-assembly mechanisms of active ingredients into PMs, the anticancer activities of PMs associated with various cell death pathways, and the research cases of PMs as drug delivery vehicles in cancer therapy are described. Finally, this review summarizes the status of the clinical trials and real-world applications of PMs and briefly analyzes the reasons for the unsatisfactory commercialized states. This review supports further research on the role of PMs as nanocarriers in cancer therapy and adds insights for the successful clinical translation of PM-based products.
Open peer comments: Debate/Discuss/Question/Opinion
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