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Bio-Design and Manufacturing  2026 Vol.9 No.1 P.165 - 181

http://doi.org/10.1631/bdm.2500298


Bonding heterostructure mediated “photo-thermo-electric” implant: NIR-II photothermal and thermoelectric therapy for bone tumor defects


Author(s):  Jun Zan, Jiachi Zhao, Jie Zeng, Qian Yang, Hengyun Ye, Youwen Yang, Cijun Shuai

Affiliation(s):  1. School of Sino-German Robotics, Shenzhen University of Information Technology, Shenzhen, 518172, China more

Corresponding email(s):   yangyouwen@jxust.edu.cn, yangyouwen@jxust.edu.cn

Key Words:  Antitumor bone scaffolds, Photo-thermo-electric therapy, Near-infrared II window, Bonding heterostructures, Selective laser sintering


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Jun Zan. Bonding heterostructure mediated “photo-thermo-electric” implant: NIR-II photothermal and thermoelectric therapy for bone tumor defects[J]. Journal of Zhejiang University Science D, 2026, 9(1): 165 - 181.

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Abstract: 
Recurrence of solid tumors after surgical resection is a major barrier to tissue regeneration. As an emerging treatment strategy, photo-thermo-electric therapy ablates tumor cells via photothermal effects and generates reactive oxygen species (ROS) via thermoelectric effects to disrupt heat shock proteins, thereby suppressing their protective function in tumor cells. However, conventional materials suffer from low thermoelectric efficiency and weak tissue penetration ability. In this study, we fabricated iodine-doped bismuth sulfide (I-Bi2S3) nanorods with bonding heterostructures to improve thermoelectric performance. The approach employed iodine doping to introduce additional electrons, thereby regulating the band structure of Bi2S3and exploiting the dual low-energy vibration effect of the heterostructures to reduce thermal conductivity. More importantly, controlling the type of heterostructure modulated the bandgap width, thereby expanding the light absorption range to the higher-penetration near-infrared (NIR)-II region for deep tissue treatment. The I-Bi2S3nanorods were incorporated into poly-l-lactic acid (PLLA) scaffolds to confer antitumor functionality. According to the results, the bonding heterostructures enhanced the conductivity of Bi2S3and reduced its thermal conductivity, significantly enhancing thermoelectric efficacy. The heterostructures reduced the bandgap of Bi2S3from 1.23 to 0.88 eV, enabling optical absorption in the NIR-II region. The ROS tests showed that the PLLA/I-Bi2S3scaffold exhibited good photothermal effects and ROS generation under 1064-nm laser irradiation. The antitumor efficacy of the PLLA/I-Bi2S3scaffold reached 84.6% against MG-63 cells, demonstrating its exceptional potential in cancer treatment.

Bonding heterostructure mediated “photo-thermo-electric” implant: NIR-II photothermal and thermoelectric therapy for bone tumor defects

实体瘤手术切除后的复发是组织再生的主要障碍。 光热电联合疗法作为一种新兴的治疗策略, 能通过光热效应消融肿瘤细胞, 同时利用热电效应产生活性氧 (ROS), 破坏热休克蛋白, 从而抑制肿瘤细胞的保护机制。 然而, 传统的光热电材料普遍存在热电效率低和组织穿透能力弱的问题。 本研究制备了具有键合异质结构的碘掺杂硫化铋 (I-Bi2S3) 纳米棒以提高其热电性能。 具体而言, 通过碘掺杂引入额外电子以调控 Bi2S3的能带结构, 并利用异质结构的双低能振动效应降低材料热导率。 更重要的是, 通过调控异质结构类型可调节能带带隙宽度, 将光吸收范围拓展至穿透力更强的近红外二区 (NIR-II), 从而实现深层组织治疗。 进一步将 I-Bi2S3纳米棒引入左旋聚乳酸 (PLLA) 支架, 赋予支架抗肿瘤功能。 结果表明, 异质结构的构建显著提高了 Bi2S3的电导率并降低了其热导率, 从而显著增强了热电性能。 此外, 异质结构使 Bi2S3的带隙从 1.23 eV 降低至 0.88 eV, 实现了 NIR-II 区的光吸收。 ROS 测试结果表明在 1064 nm 激光照射下 PLLA/I-Bi2S3支架表现出良好的光热效应和 ROS 生成能力。 该支架对 MG-63 骨肉瘤细胞的抗肿瘤效率达 84.6%, 展现出其在肿瘤治疗领域的卓越潜力。
Antitumor bone scaffolds; Photo-thermo-electric therapy; Near-infrared II window; Bonding heterostructures; Selective laser sintering

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