CLC number: TG146.13; TG665; R318.08
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2020-10-16
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Ci-jun Shuai, Ming-li Yang, Fang Deng, You-wen Yang, Shu-ping Peng, Fang-wei Qi, Chong-xian He, Li-da Shen, Hui-xin Liang. Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy[J]. Journal of Zhejiang University Science A, 2020, 21(11): 876-891.
@article{title="Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy",
author="Ci-jun Shuai, Ming-li Yang, Fang Deng, You-wen Yang, Shu-ping Peng, Fang-wei Qi, Chong-xian He, Li-da Shen, Hui-xin Liang",
journal="Journal of Zhejiang University Science A",
volume="21",
number="11",
pages="876-891",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.A2000186"
}
%0 Journal Article
%T Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy
%A Ci-jun Shuai
%A Ming-li Yang
%A Fang Deng
%A You-wen Yang
%A Shu-ping Peng
%A Fang-wei Qi
%A Chong-xian He
%A Li-da Shen
%A Hui-xin Liang
%J Journal of Zhejiang University SCIENCE A
%V 21
%N 11
%P 876-891
%@ 1673-565X
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A2000186
TY - JOUR
T1 - Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy
A1 - Ci-jun Shuai
A1 - Ming-li Yang
A1 - Fang Deng
A1 - You-wen Yang
A1 - Shu-ping Peng
A1 - Fang-wei Qi
A1 - Chong-xian He
A1 - Li-da Shen
A1 - Hui-xin Liang
J0 - Journal of Zhejiang University Science A
VL - 21
IS - 11
SP - 876
EP - 891
%@ 1673-565X
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A2000186
Abstract: Zinc (Zn) has recently been recognized as a promising bone repair material due to its inherent biodegradability and favorable biocompatibility. In this work, rare earth neodymium (Nd) was introduced into a Zn-based alloy fabricated using a laser powder bed fusion (LPBF) process. Results showed that addition of Nd significantly improved the melt fluidity and reduced the evaporation of Zn, thereby achieving parts with a high densification rate of 98.71%. Significantly, the nd alloying treatment effectively refined the grain size from 25.3 to 6.2 μm. NdZn5 eutectics precipitated and contributed to a second-phase strengthening effect. As a result, the tensile strength increased to (119.3±5.1) MPa and the Vickers hardness to (76.2±4.1). Moreover, the zn–;nd alloy exhibited good anti-inflammatory activity, as the Nd ions released during degradation had a strong affinity with cell membrane phospholipids and consequently inhibited the release of inflammatory cytokines. It also presented favorable cytocompatibility, showing great potential as a bone repair material.
[1]ASTM (American Society for Testing and Materials), 2004. Standard Practice for Laboratory Immersion Corrosion Testing of Metals, ASTM G31-72:2004. ASTM, West Conshohocken, USA.
[2]Baltaci AK, Yuce K, Mogulkoc R, 2018. Zinc metabolism and metallothioneins. Biological Trace Element Research, 183(1):22-31.
[3]Brooks AJ, Yao H, Yuan J, et al., 2018. Early detection of fracture failure in SLM AM tension testing with Talbot-Lau neutron interferometry. Additive Manufacturing, 22: 658-664.
[4]Cao Y, Shi TS, Jiao C, et al., 2020. Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing. Ceramics International, 46(2):2300-2308.
[5]Das T, Sharma A, Talukder G, 1988. Effects of lanthanum in cellular systems. Biological Trace Element Research, 18(1):201-228.
[6]Gao CD, Yao M, Shuai CJ, et al., 2019. Nano-Sic reinforced Zn biocomposites prepared via laser melting: microstructure, mechanical properties and biodegradability. Journal of Materials Science & Technology, 35(11):2608-2617.
[7]Gu DD, Hagedorn YC, Meiners W, et al., 2011. Nanocrystalline TiC reinforced Ti matrix bulk-form nanocomposites by selective laser melting (SLM): densification, growth mechanism and wear behavior. Composites Science and Technology, 71(13):1612-1620.
[8]He SW, Yang S, Zhang YR, et al., 2019. LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis. Cell Death & Disease, 10(12):947.
[9]Hou Y, Jia GZ, Yue R, et al., 2018. Synthesis of biodegradable Zn-based scaffolds using NaCl templates: relationship between porosity, compressive properties and degradation behavior. Materials Characterization, 137:162-169.
[10]ISO (International Organization for Standardization), 2009. Biological Evaluation of Medical Devices—Part 5: Tests for in Vitro Cytotoxicity, ISO 10993-5:2009. ISO, Geneva, Switzerland.
[11]ISO (International Organization for Standardization), 2019. Plastics—Determination of Tensile Properties—Part 1: General Principles, ISO 527-1:2019. ISO, Geneva, Switzerland.
[12]Jiang C, Zou Y, Liu X, et al., 2013. Dose-dependent effects of lanthanum chloride on wear particle-induced aseptic inflammation in a murine air-pouch model. Journal of Rare Earths, 31(4):420-427.
[13]Jin L, Chen CX, Li YT, et al., 2019. A biodegradable Mg-based alloy inhibited the inflammatory response of THP-1 cell-derived macrophages through the TRPM7-PI3K-AKT1 signaling axis. Frontiers in Immunology, 10: 2798.
[14]Krivilyov M, Volkmann T, Gao J, et al., 2012. Multiscale analysis of the effect of competitive nucleation on phase selection in rapid solidification of rare-earth ternary magnetic materials. Acta Materialia, 60(1):112-122.
[15]Li HF, Zheng YF, Qin L, 2014. Progress of biodegradable metals. Progress in Natural Science: Materials International, 24(5):414-422.
[16]Li P, Schille C, Schweizer E, et al., 2019. Selection of extraction medium influences cytotoxicity of zinc and its alloys. Acta Biomaterialia, 98:235-245.
[17]Li RB, Ji ZX, Qin HQ, et al., 2014. Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome. ACS Nano, 8(10):10280-10292.
[18]Li W, Jiang HX, Zhang LL, et al., 2019. Solidification of Al-Bi-Sn immiscible alloy under microgravity conditions of space. Scripta Materialia, 162:426-431.
[19]Liang HX, Yang YW, Xie DQ, et al., 2019. Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility. Journal of Materials Science & Technology, 35(7):1284-1297.
[20]Liu J, Gu DD, Chen HY, et al., 2018. Influence of substrate surface morphology on wetting behavior of tracks during selective laser melting of aluminum-based alloys. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 19(2):111-121.
[21]Montani M, Demir AG, Mostaed E, et al., 2017. Processability of pure Zn and pure Fe by SLM for biodegradable metallic implant manufacturing. Rapid Prototyping Journal, 23(3):514-523.
[22]Niu JL, Tang ZB, Huang H, et al., 2016. Research on a Zn-Cu alloy as a biodegradable material for potential vascular stents application. Materials Science and Engineering: C, 69:407-413.
[23]Pariona MM, Micene KT, 2019. Effect of microstructure on microhardness and electrochemical behavior in hypereutectic Al-Fe alloy processed by laser surface remelting. In: Dekoulis G (Ed.), Aerospace Engineering. IntechOpen, London, UK.
[24]Paz R, Monzón MD, Bertrand P, et al., 2019. Comparison of different cellular structures for the design of selective laser melting parts through the application of a new lightweight parametric optimisation method. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 20(2):117-132.
[25]Plotkowski A, Rios O, Sridharan N, et al., 2017. Evaluation of an Al-Ce alloy for laser additive manufacturing. Acta Materialia, 126:507-519.
[26]Qian XY, Zeng Y, Jiang B, et al., 2019. Grain refinement mechanism and improved mechanical properties in Mg–Sn alloy with trace Y addition. Journal of Alloys and Compounds, 820:153122.
[27]Shi MC, Xia LG, Chen ZT, et al., 2017. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent. Biomaterials, 144:176-187.
[28]Shuai CJ, Yang YW, Peng SP, et al., 2017. Nd-induced honeycomb structure of intermetallic phase enhances the corrosion resistance of Mg alloys for bone implants. Journal of Materials Science: Materials in Medicine, 28(9):130.
[29]Shuai CJ, Li YL, Yang YW, et al., 2019a. Bioceramic enhances the degradation and bioactivity of iron bone implant. Materials Research Express, 6(11):115401.
[30]Shuai CJ, Liu GF, Yang YW, et al., 2019b. Construction of an electric microenvironment in piezoelectric scaffolds fabricated by selective laser sintering. Ceramics International, 45(16):20234-20242.
[31]Shuai CJ, Yu L, Feng P, et al., 2020a. Interfacial reinforcement in bioceramic/biopolymer composite bone scaffold: the role of coupling agent. Colloids and Surfaces B: Biointerfaces, 193:111083.
[32]Shuai CJ, Wang B, Bin SZ, et al., 2020b. Interfacial strengthening by reduced graphene oxide coated with MgO in biodegradable Mg composites. Materials & Design, 191: 108612.
[33]Shuai CJ, Cheng Y, Yang WJ, et al., 2020c. Magnetically actuated bone scaffold: microstructure, cell response and osteogenesis. Composites Part B: Engineering, 192: 107986.
[34]Shuai CJ, Li S, Yang WJ, et al., 2020d. MnO2 catalysis of oxygen reduction to accelerate the degradation of Fe-C composites for biomedical applications. Corrosion Science, 170:108679.
[35]Shuai CJ, Dong Z, He CX, et al., 2020e. A peritectic phase refines the microstructure and enhances Zn implants. Journal of Materials Research and Technology, 9(3):2623-2634.
[36]Shuai CJ, Liu GG, Yang YW, et al., 2020f. A strawberry-like Ag-decorated barium titanate enhances piezoelectric and antibacterial activities of polymer scaffold. Nano Energy, 74:104825.
[37]Shuai CJ, Wang B, Bin SZ, et al., 2020g. TiO2-induced in situ reaction in graphene oxide-reinforced AZ61 biocomposites to enhance the interfacial bonding. ACS Applied Materials & Interfaces, 12(20):23464-23473.
[38]Tang ZB, Huang H, Niu JL, et al., 2017. Design and characterizations of novel biodegradable Zn-Cu-Mg alloys for potential biodegradable implants. Materials & Design, 117:84-94.
[39]Wang D, Wu SB, Fu F, et al., 2017. Mechanisms and characteristics of spatter generation in SLM processing and its effect on the properties. Materials & Design, 117:121-130.
[40]Wang GY, He CX, Yang WJ, et al., 2020. Surface-modified graphene oxide with compatible interface enhances poly-L-lactic acid bone scaffold. Journal of Nanomaterials, 2020:5634096.
[41]Wang MF, Xiao DH, Zhou PF, et al., 2018. Effects of rare earth yttrium on microstructure and properties of Mg-Al-Zn alloy. Journal of Alloys and Compounds, 742: 232-239.
[42]Wang P, Liu J, Shen S, et al., 2019. In vitro and in vivo studies on two-step alkali-fluoride-treated Mg-Zn-Y-Nd alloy for vascular stent application: enhancement in corrosion resistance and biocompatibility. ACS Biomaterials Science & Engineering, 5(7):3279-3292.
[43]Wang QD, Lu YZ, Zeng XQ, et al., 1999. Study on the fluidity of AZ91+xRE magnesium alloy. Materials Science and Engineering: A, 271(1-2):109-115.
[44]Wei KW, Zeng XY, Wang ZM, et al., 2019. Selective laser melting of Mg-Zn binary alloys: effects of Zn content on densification behavior, microstructure, and mechanical property. Materials Science and Engineering: A, 756: 226-236.
[45]Wen P, Jauer L, Voshage M, et al., 2018a. Densification behavior of pure Zn metal parts produced by selective laser melting for manufacturing biodegradable implants. Journal of Materials Processing Technology, 258:128-137.
[46]Wen P, Voshage M, Jauer L, et al., 2018b. Laser additive manufacturing of Zn metal parts for biodegradable applications: processing, formation quality and mechanical properties. Materials & Design, 155:36-45.
[47]Wu XF, Zhang GA, Wu FF, et al., 2013. Influence of neodymium addition on microstructure, tensile properties and fracture behavior of cast Al-Mg2Si metal matrix composite. Journal of Rare Earths, 31(3):307-312.
[48]Xu XY, Chen XH, Du WW, et al., 2017. Effect of Nd on microstructure and mechanical properties of as-extruded Mg-Y-Zr-Nd alloy. Journal of Materials Science & Technology, 33(9):926-934.
[49]Yang WJ, Zhong YC, He CX, et al., 2020. Electrostatic self-assembly of pFE3O4 nanoparticles on graphene oxide: a co-dispersed nanosystem reinforces PLLA scaffolds. Journal of Advanced Research, 24:191-203.
[50]Yang YW, Yuan FL, Gao CD, et al., 2018. A combined strategy to enhance the properties of Zn by laser rapid solidification and laser alloying. Journal of the Mechanical Behavior of Biomedical Materials, 82:51-60.
[51]Yang YW, He CX, E DY, et al., 2020. Mg bone implant: features, developments and perspectives. Materials & Design, 185:108259.
[52]Yang YW, Cheng Y, Peng SP, et al., 2021. Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold. Bioactive Materials, 6(5):1230-1241.
[53]Yao CZ, Wang ZC, Tay SL, et al., 2014. Effects of Mg on microstructure and corrosion properties of Zn–Mg alloy. Journal of Alloys and Compounds, 602:101-107.
[54]Yao H, Zhang YJ, Liu L, et al., 2016. Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca2+ influx. Biomaterials, 108:143-156.
[55]Yin HY, Xu LB, Porter NA, 2011. Free radical lipid peroxidation: mechanisms and analysis. Chemical Reviews, 111(10):5944-5972.
[56]Yue R, Zhang J, Ke GZ, et al., 2019. Effects of extrusion temperature on microstructure, mechanical properties and in vitro degradation behavior of biodegradable Zn-3Cu-0.5Fe alloy. Materials Science and Engineering: C, 105: 110106.
[57]Zhu DY, Lu B, Yin JH, et al., 2019. Gadolinium-doped bioglass scaffolds promote osteogenic differentiation of hBMSC via the Akt/GSK3β pathway and facilitate bone repair in vivo. International Journal of Nanomedicine, 14:1085-1100.
[58]Zhu SM, Wu CC, Li GN, et al., 2019. Creep properties of biodegradable Zn-0.1Li alloy at human body temperature: implications for its durability as stents. Materials Research Letters, 7(9):347-353.
[59]Zhu Y, Zou J, Yang HY, 2018. Wear performance of metal parts fabricated by selective laser melting: a literature review. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 19(2):95-110.
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