Full Text:   <117>

CLC number: 

On-line Access: 2024-03-26

Received: 2023-07-22

Revision Accepted: 2023-09-07

Crosschecked: 0000-00-00

Cited: 0

Clicked: 165

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2024 Vol.7 No.2 P.105-120

http://doi.org/10.1007/s42242-023-00264-0


Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity


Author(s):  Cijun Shuai, Xiaoxin Shi, Kai Wang, Yulong Gu, Feng Yang & Pei Feng

Affiliation(s):  State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China; more

Corresponding email(s):   fengpei@csu.edu.cn

Key Words:  Ag-doped, Carbon nanotube/hydroxyapatite (CNT/HAP), Antibacterial properties, Bone scaffold


Share this article to: More

Cijun Shuai, Xiaoxin Shi, Kai Wang, Yulong Gu, Feng Yang & Pei Feng. Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity[J]. Journal of Zhejiang University Science D, 2024, 7(2): 105-120.

@article{title="Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity",
author="Cijun Shuai, Xiaoxin Shi, Kai Wang, Yulong Gu, Feng Yang & Pei Feng",
journal="Journal of Zhejiang University Science D",
volume="7",
number="2",
pages="105-120",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00264-0"
}

%0 Journal Article
%T Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity
%A Cijun Shuai
%A Xiaoxin Shi
%A Kai Wang
%A Yulong Gu
%A Feng Yang & Pei Feng
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 2
%P 105-120
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00264-0

TY - JOUR
T1 - Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity
A1 - Cijun Shuai
A1 - Xiaoxin Shi
A1 - Kai Wang
A1 - Yulong Gu
A1 - Feng Yang & Pei Feng
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 2
SP - 105
EP - 120
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00264-0


Abstract: 
Bacterial infection is a major problem following bone implant surgery. Moreover, poly-l-lactic acid/carbon nanotube/hydroxyapatite (PLLA/CNT/HAP) bone scaffolds possess enhanced mechanical properties and show good bioactivity regarding bone defect regeneration. In this study, we synthesized silver (Ag)-doped CNT/HAP (CNT/Ag-HAP) nanohybrids via the partial replacing of calcium ions (Ca2+) in the HAP lattice with silver ions (Ag+) using an ion doping technique under hydrothermal conditions. Specifically, the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT, and involved the partial replacement of Ca2+ in the HAP lattice by doped Ag+ as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal environment. The resulting CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion (PBF-LB) to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial activity. We then found that Ag+, which possesses broad-spectrum antibacterial activity, endowed PLLA/CNT/Ag-HAP scaffolds with this activity, with an antibacterial effectiveness of 92.65%. This antibacterial effect is due to the powerful effect of Ag+ against bacterial structure and genetic material, as well as the physical destruction of bacterial structures due to the sharp edge structure of CNT. In addition, the scaffold possessed enhanced mechanical properties, showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa, respectively. Finally, the scaffold also exhibited good bioactivity and cytocompatibility, including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells (MG63 cells).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE