Similar articles

Abstract: The fabrication of constructs with gradients for chemical, mechanical, or electrical composition is becoming critical to achieving more complex structures, particularly in 3D printing and biofabrication. This need is underscored by the complexity of in vivo tissues, which exhibit heterogeneous structures comprised of diverse cells and matrices. Drawing inspiration from the classical Tesla valve, our study introduces a new concept of micromixers to address this complexity. The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids. Notably, our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles, which represents a significant improvement over the traditional mixing method. This advance is pivotal for the field of 3D printing and bioprinting, and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.

一种能显著提升牛顿和非牛顿流体混合效率的新型3D特斯拉微混匀器

[1]AazmiA, ZhouHZ, LvWK, et al., 2022. Vascularizing the brain in vitro. iScience, 25(4):104110.

[2]AazmiA, ZhangD, MazzagliaC, et al., 2024. Biofabrication methods for reconstructing extracellular matrix mimetics. Bioactive Materials, 31:475-496.

[3]AbolpourB, HekmatkhahR, ShamsoddiniR, 2022. Optimum design for the Tesla micromixer. Microfluidics and Nanofluidics, 26(6):46.

[4]AgrawalR, KumarA, MohammedMKA, et al., 2023. Biomaterial types, properties, medical applications, and other factors: a recent review. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 24(11):1027-1042.

[5]ArmeniadesCD, JohnsonWC, ThomasR, 1966. Mixing Device. US Patent 3286992.

[6]BayarehM, AshaniMN, UsefianA, 2020. Active and passive micromixers: a comprehensive review. Chemical Engineering and Processing-Process Intensification, 147:107771.

[7]BeckerE, 1980. Simple non-Newtonian fluid flows. Advances in Applied Mechanics, 20:177-226.

[8]Bolívar-MonsalveEJ, Ceballos-GonzálezCF, Borrayo-MontañoKI, et al., 2021. Continuous chaotic bioprinting of skeletal muscle-like constructs. Bioprinting, 21:e00125.

[9]BuglieWLN, TamrinKF, SheikhNA, et al., 2022. Enhanced fluid mixing using a reversed multistage Tesla micromixer. Chemical Engineering & Technology, 45(7):1255-1263.

[10]Chávez-MaderoC, de León-DerbyMD, SamandariM, et al., 2020. Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro- and nanostructures: continuous chaotic printing. Biofabrication, 12(3):035023.

[11]ChenYB, NiuZH, JiangWQ, et al., 2021. 3D-printed models improve surgical planning for correction of severe postburn ankle contracture with an external fixator. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 22(10):866-875.

[12]Florián-AlgarínV, AcevedoA, 2010. Rheology and thermotropic gelation of aqueous sodium alginate solutions. Journal of Pharmaceutical Innovation, 5(1):37-44.

[13]HolmbergS, Garza-FloresNA, AlmajhadiMA, et al., 2021. Fabrication of multilayered composite nanofibers using continuous chaotic printing and electrospinning: chaotic electrospinning. ACS Applied Materials & Interfaces, 13(31):37455-37465.

[14]KhandelwalV, DhimanA, BaranyiL, 2015. Laminar flow of non-Newtonian shear-thinning fluids in a T-channel. Computers & Fluids, 108:79-91.

[15]KingRP, 2002. Non-Newtonian slurries. In: King RP (Ed.), Introduction to Practical Fluid Flow. Butterworth-Heinemann, Oxford, UK, p.117-157.

[16]KokkinisD, BouvilleF, StudartAR, 2018. 3D printing of materials with tunable failure via bioinspired mechanical gradients. Advanced Materials, 30(19):1705808.

[17]LiuWJ, ZhangYS, HeinrichMA, et al., 2017. Rapid continuous multimaterial extrusion bioprinting. Advanced Materials, 29(3):1604630.

[18]MaJY, LinYB, ChenXL, et al., 2014. Flow behavior, thixotropy and dynamical viscoelasticity of sodium alginate aqueous solutions. Food Hydrocolloids, 38:119-128.

[19]MehtaV, RathSN, 2021. 3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare. Bio-Design and Manufacturing, 4(2):311-343.

[20]MonzónM, 2018. Biomaterials and additive manufacturing: osteochondral scaffold innovation applied to osteoarthritis (BAMOS project). Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 19(4):329-330.

[21]NguyenNT, WuZG, 2005. Micromixers—a review. Journal of Micromechanics and Microengineering, 15(2):R1-R16.

[22]NyandeBW, ThomasKM, LakerveldR, 2021. CFD analysis of a kenics static mixer with a low pressure drop under laminar flow conditions. Industrial & Engineering Chemistry Research, 60(14):5264-5277.

[23]PoologasundarampillaiG, HaweetA, JayashSN, et al., 2021. Real-time imaging and analysis of cell-hydrogel interplay within an extrusion-bioprinting capillary. Bioprinting, 23:e00144.

[24]RamezaniH, ZhouLY, ShaoL, et al., 2020. Coaxial 3D bioprinting of organ prototyps from nutrients delivery to vascularization. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 21(11):859-875.

[25]RastogiP, KandasubramanianB, 2019. Review of alginate-based hydrogel bioprinting for application in tissue engineering. Biofabrication, 11(4):042001.

[26]Rodríguez-RiveroC, HilliouL, Martín del ValleEM, et al., 2014. Rheological characterization of commercial highly viscous alginate solutions in shear and extensional flows. Rheologica Acta, 53(7):559-570.

[27]Sánchez-SánchezR, Rodríguez-RegoJM, Macías-GarcíaA, et al., 2023. Relationship between shear-thinning rheological properties of bioinks and bioprinting parameters. International Journal of Bioprinting, 9(2):687.

[28]Skylar-ScottMA, MuellerJ, VisserCW, et al., 2019. Voxelated soft matter via multimaterial multinozzle 3D printing. Nature, 575(7782):330-335.

[29]TavafoghiM, DarabiMA, MahmoodiM, et al., 2021. Multimaterial bioprinting and combination of processing techniques towards the fabrication of biomimetic tissues and organs. Biofabrication, 13(4):042002.

[30]ValdésJP, KahouadjiL, MatarOK, 2022. Current advances in liquid–liquid mixing in static mixers: a review. Chemical Engineering Research and Design, 177:694-731.

[31]XiongYT, KangHY, ZhouHZ, et al., 2022. Recent progress on microfluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle (EV) separation. Bio-Design and Manufacturing, 5(3):607-616.

[32]ZhangB, XueQ, HuHY, et al., 2019. Integrated 3D bioprinting-based geometry-control strategy for fabricating corneal substitutes. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 20(12):945-959.

[33]ZhangHL, YaoY, HuiY, et al., 2022. A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing. Bio-Design and Manufacturing, 5(1):210-219.

[34]ZhouHZ, LiuP, GaoZQ, et al., 2022. Simultaneous multimaterial multimethod bioprinting. Bio-Design and Manufacturing, 5(3):433-436.