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On-line Access: 2021-07-06
Received: 2021-03-01
Revision Accepted: 2021-06-09
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In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
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Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung. In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer[J]. Journal of Zhejiang University Science D, 2021, 4(4): 879-888.
@article{title="In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer",
author="Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="879-888",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00147-2"
}
%0 Journal Article
%T In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
%A Jong Woong Park
%A Ye Chan Shin
%A Hyun Guy Kang
%A Sangeun Park
%A Eunhyeok Seo
%A Hyokyung Sung
%A Im Doo Jung
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 879-888
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00147-2
TY - JOUR
T1 - In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
A1 - Jong Woong Park
A1 - Ye Chan Shin
A1 - Hyun Guy Kang
A1 - Sangeun Park
A1 - Eunhyeok Seo
A1 - Hyokyung Sung
A1 - Im Doo Jung
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 879
EP - 888
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00147-2
Abstract: Cancer growth in the bone due to its random shape disables bone strength and thus changes its capacity to support body
weight or muscles, which can crucially afect the quality of human life in terms of normal walking or daily activities. For
successful patient recovery, it is necessary to remove the cancer-afected minimal bone area and quickly replace it with a
biocompatible metal implant within less than 2 weeks. An electron beam-melted Ti-6Al-4V implant was designed and applied
in a patient to preserve the natural knee joint close to the bone tumor. The developed implant fts the bone defect well, and
the independent ambulatory function of the natural knee joint was restored in the patient within six weeks after surgery. A
delayed fracture occurred six months after the successful replacement of cancer-afected bone with Ti-6Al-4V implant at the
proximal meshed junction of the implant because of a minor downward slip. Microstructural, mechanical, and computational
analyses were conducted for the fractured area to fnd the main reason for the delayed fracture. Our fndings pertaining to
the mechanical and material investigation can help realize the safe implantation of the three-dimensionally printed titanium
implant to preserve the natural joints of patients with massive bone defects of the extremities.
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