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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.879-888

http://doi.org/10.1007/s42242-021-00147-2


In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer


Author(s):  Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung

Affiliation(s):  Division of Convergence Technology, National Cancer Center, Goyang 10408, Republic of Korea; more

Corresponding email(s):   hksung@gnu.ac.kr, idjung@unist.ac.kr

Key Words:  3D printing, Bone cancer, Titanium alloy implant, Electron beam melting, Fracture analysis


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Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung. In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer[J]. Journal of Zhejiang University Science D, 2021, 4(4): 879-888.

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author="Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="879-888",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00147-2"
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%T In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
%A Jong Woong Park
%A Ye Chan Shin
%A Hyun Guy Kang
%A Sangeun Park
%A Eunhyeok Seo
%A Hyokyung Sung
%A Im Doo Jung
%J Journal of Zhejiang University SCIENCE D
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%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00147-2

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T1 - In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
A1 - Jong Woong Park
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A1 - Hyun Guy Kang
A1 - Sangeun Park
A1 - Eunhyeok Seo
A1 - Hyokyung Sung
A1 - Im Doo Jung
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DOI - 10.1007/s42242-021-00147-2


Abstract: 
Cancer growth in the bone due to its random shape disables bone strength and thus changes its capacity to support body weight or muscles, which can crucially afect the quality of human life in terms of normal walking or daily activities. For successful patient recovery, it is necessary to remove the cancer-afected minimal bone area and quickly replace it with a biocompatible metal implant within less than 2 weeks. An electron beam-melted Ti-6Al-4V implant was designed and applied in a patient to preserve the natural knee joint close to the bone tumor. The developed implant fts the bone defect well, and the independent ambulatory function of the natural knee joint was restored in the patient within six weeks after surgery. A delayed fracture occurred six months after the successful replacement of cancer-afected bone with Ti-6Al-4V implant at the proximal meshed junction of the implant because of a minor downward slip. Microstructural, mechanical, and computational analyses were conducted for the fractured area to fnd the main reason for the delayed fracture. Our fndings pertaining to the mechanical and material investigation can help realize the safe implantation of the three-dimensionally printed titanium implant to preserve the natural joints of patients with massive bone defects of the extremities.

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