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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.879-888

http://doi.org/10.1007/s42242-021-00147-2


In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer


Author(s):  Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung

Affiliation(s):  Division of Convergence Technology, National Cancer Center, Goyang 10408, Republic of Korea; more

Corresponding email(s):   hksung@gnu.ac.kr, idjung@unist.ac.kr

Key Words:  3D printing, Bone cancer, Titanium alloy implant, Electron beam melting, Fracture analysis


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Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung. In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer[J]. Journal of Zhejiang University Science D, 2021, 4(4): 879-888.

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author="Jong Woong Park, Ye Chan Shin, Hyun Guy Kang, Sangeun Park, Eunhyeok Seo, Hyokyung Sung, Im Doo Jung",
journal="Journal of Zhejiang University Science D",
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pages="879-888",
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publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00147-2"
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%T In vivo analysis of post‑joint‑preserving surgery fracture of 3D‑printed Ti‑6Al‑4V implant to treat bone cancer
%A Jong Woong Park
%A Ye Chan Shin
%A Hyun Guy Kang
%A Sangeun Park
%A Eunhyeok Seo
%A Hyokyung Sung
%A Im Doo Jung
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A1 - Jong Woong Park
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A1 - Hyun Guy Kang
A1 - Sangeun Park
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Abstract: 
Cancer growth in the bone due to its random shape disables bone strength and thus changes its capacity to support body weight or muscles, which can crucially afect the quality of human life in terms of normal walking or daily activities. For successful patient recovery, it is necessary to remove the cancer-afected minimal bone area and quickly replace it with a biocompatible metal implant within less than 2 weeks. An electron beam-melted Ti-6Al-4V implant was designed and applied in a patient to preserve the natural knee joint close to the bone tumor. The developed implant fts the bone defect well, and the independent ambulatory function of the natural knee joint was restored in the patient within six weeks after surgery. A delayed fracture occurred six months after the successful replacement of cancer-afected bone with Ti-6Al-4V implant at the proximal meshed junction of the implant because of a minor downward slip. Microstructural, mechanical, and computational analyses were conducted for the fractured area to fnd the main reason for the delayed fracture. Our fndings pertaining to the mechanical and material investigation can help realize the safe implantation of the three-dimensionally printed titanium implant to preserve the natural joints of patients with massive bone defects of the extremities.

韩国庆尚大学Hyokyung Sung等 | 3D打印Ti-6Al-4V植入物关节保留术后骨折治疗骨癌的临床分析

本研究论文聚焦使用3D打印金属植入物治疗骨癌的临床应用。由于其随机形状,骨癌生长会降低骨骼强度,从而改变其支持体重或肌肉的能力。这会影响正常行走或日常活动,从而严重影响人类的生活质量。为了使患者成功康复,有必要尽快切除受癌症影响的最小骨区域,并在两周内迅速用生物相容性好的金属植入物替换。本研究设计并在患者体内安装了电子束熔融的Ti-6Al-4V植入物,以保存靠近骨肿瘤的天然膝关节。所开发的植入物与骨缺损吻合性好,并且在手术后六周内恢复了自然膝关节的独立行走功能。在Ti-6Al-4V植入物成功替换受癌症影响的骨后六个月,由于植入物近端的网状交界处轻微向下滑移,患者发生了延迟性骨折。本文作者对断裂区域进行了微观结构、力学和计算分析,并找出延迟断裂的主要原因。本文关于机械和材料研究的发现可以帮助实现3D打印钛植入物的安全植入,以保护四肢有大量骨缺损的患者的自然关节。

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