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3D printing of wet-bonded multilayer scaffolds for skin wound repair
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Kangning SHEN1,2, Jingyi GU3, Ximin YUAN4, Nian LIU4, Yinglin WANG3, Jiabin CAI1,2, Yang SHI3, Kaiyang WANG4, Xinghua YE2,Minghao YANG2, Zhiyong MA1,2, Zhijian XIE3. 3D printing of wet-bonded multilayer scaffolds for skin wound repair[J]. Journal of Zhejiang University Science A, 1998, -1(-1): .
@article{title="3D printing of wet-bonded multilayer scaffolds for skin wound repair",
author="Kangning SHEN1,2, Jingyi GU3, Ximin YUAN4, Nian LIU4, Yinglin WANG3, Jiabin CAI1,2, Yang SHI3, Kaiyang WANG4, Xinghua YE2,Minghao YANG2, Zhiyong MA1,2, Zhijian XIE3",
journal="Journal of Zhejiang University Science A",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.A2500653"
}
%0 Journal Article
%T 3D printing of wet-bonded multilayer scaffolds for skin wound repair
%A Kangning SHEN1
%A 2
%A Jingyi GU3
%A Ximin YUAN4
%A Nian LIU4
%A Yinglin WANG3
%A Jiabin CAI1
%A 2
%A Yang SHI3
%A Kaiyang WANG4
%A Xinghua YE2
%A Minghao YANG2
%A Zhiyong MA1
%A 2
%A Zhijian XIE3
%J Journal of Zhejiang University SCIENCE A
%V -1
%N -1
%P
%@ 1673-565X
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A2500653
TY - JOUR
T1 - 3D printing of wet-bonded multilayer scaffolds for skin wound repair
A1 - Kangning SHEN1
A1 - 2
A1 - Jingyi GU3
A1 - Ximin YUAN4
A1 - Nian LIU4
A1 - Yinglin WANG3
A1 - Jiabin CAI1
A1 - 2
A1 - Yang SHI3
A1 - Kaiyang WANG4
A1 - Xinghua YE2
A1 - Minghao YANG2
A1 - Zhiyong MA1
A1 - 2
A1 - Zhijian XIE3
J0 - Journal of Zhejiang University Science A
VL - -1
IS - -1
SP -
EP -
%@ 1673-565X
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A2500653
Abstract: The skin repair process is significantly influenced by the regulation of a dynamic mechanical microenvironment. However, traditional single-layer scaffolds face limitations, including poor mechanical compatibility and weak interfacial adhesion. These drawbacks stem from their inability to mimic the multi-layered heterogeneous structure and functional synergy of natural skin. In this paper, a biomimetic skin extracellular matrix (ECM) scaffold with a layered structure BPS is proposed, consisting of three layers: a surface layer (SL), a support layer (PL), and a base layer (BL). The SL consists of a 3D-printed microporous polycaprolactone (PCL) structure, which simulates the epidermal barrier's antibacterial and breathable properties. The PL, a surface-modified multilayer PCL scaffold, mimics the dermal layer and provides essential mechanical support and elasticity. The BL, a hydrogel coated onto the surface of the PL, provides excellent biological properties. genipin serves as a crosslinker, and ethylenediamine is used for amination treatment of the PCL scaffold surface. This chemical crosslinking strengthens interlayer connections, enhancing functional synergy and tripling the anti-swelling properties of the hydrogel. Additionally, it improves the wet adhesion of the scaffold to skin tissue, ensuring stable adherence to the wound surface. Compared to traditional scaffolds, this multilayer structure effectively integrates biological functions with mechanical performance, providing sustained protection and support during wound healing.
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