CLC number: R775
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2020-03-11
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Li-Juan Xu, Sha-Ling Li, Vance Zemon, Yan-Qian Xie, Yuan-Bo Liang. Central visual function and inner retinal structure in primary open-angle glaucoma[J]. Journal of Zhejiang University Science B, 2020, 21(4): 305-314.
@article{title="Central visual function and inner retinal structure in primary open-angle glaucoma",
author="Li-Juan Xu, Sha-Ling Li, Vance Zemon, Yan-Qian Xie, Yuan-Bo Liang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="4",
pages="305-314",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900506"
}
%0 Journal Article
%T Central visual function and inner retinal structure in primary open-angle glaucoma
%A Li-Juan Xu
%A Sha-Ling Li
%A Vance Zemon
%A Yan-Qian Xie
%A Yuan-Bo Liang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 4
%P 305-314
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900506
TY - JOUR
T1 - Central visual function and inner retinal structure in primary open-angle glaucoma
A1 - Li-Juan Xu
A1 - Sha-Ling Li
A1 - Vance Zemon
A1 - Yan-Qian Xie
A1 - Yuan-Bo Liang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 4
SP - 305
EP - 314
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900506
Abstract: To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma (POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential (icVEP) testing, 24-2 standard automated perimetry (SAP), and Cirrus optical coherence tomography (OCT) examinations. Signal-to-noise ratio (SNR) measures obtained from icVEP responses to isolated checks presented at four depths of modulation (DOMs; 8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity (mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness (GCL+IPLT) and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls (P<0.001). A significant positive association was found between SNR at 14% DOM and GCL+IPLT at the inferior sector in early glaucoma (r=0.465, P=0.004). In moderate to advanced glaucoma, significant correlations were found between SNR at 32% DOM and mean GCL+IPLT (r=0.364, P=0.023), superior GCL+IPLT (r=0.358, P=0.025), and mean pRNFLT (r=0.396, P=0.025). In addition, in moderate to advanced glaucoma, there were significant correlations between mMS and all relevant measures of retinal thickness (r=0.330–0.663, P< 0.010). In early glaucoma, significant correlations were found between mean mMS and minimum GCL+IPLT (r=0.373, P=0.023), and between inferior mMS and superior GCL+IPLT (r=0.470, P=0.003). Linear models provided a good explanation for the relationship between SNR and inner retinal thickness (IRT), whereas nonlinear models better explained the relationship between mMS and IRT. In early glaucoma, both SNR and mMS were related moderately and significantly to IRT, whereas in moderate to advanced glaucoma, mMS was more strongly correlated with IRT than SNR.
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