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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400167


PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4


Author(s):  Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG

Affiliation(s):  Laboratory Medicine Center, Allergy center, Department of Transfusion Medicine, Zhejiang Provincial People’ more

Corresponding email(s):   wangzhen@hmc.edu.cn, haoke@hmc.edu.cn, chenbingyu@hmc.edu.cn

Key Words:  Protein interacting with C kinase 1, Gastric cancer, Toll-like receptor 4, MYD88 signalling pathway, Autophagy


Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG. PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG",
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doi="10.1631/jzus.B2400167"
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%A Kaiqiang LI
%A Yimin YANG
%A Yaling WANG
%A Jing JIN
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%A Lina PENG
%A Aibo XU
%A Xuling LUO
%A Wei YANG
%A Peng XU
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%A Ke HAO
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A1 - Kaiqiang LI
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A1 - Yaling WANG
A1 - Jing JIN
A1 - Qianni WANG
A1 - Lina PENG
A1 - Aibo XU
A1 - Xuling LUO
A1 - Wei YANG
A1 - Peng XU
A1 - Bingyu CHEN
A1 - Ke HAO
A1 - Zhen WANG
J0 - Journal of Zhejiang University Science B
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DOI - 10.1631/jzus.B2400167


Abstract: 
protein interacting with C kinase 1 (PICK1) interacts with a variety of membrane proteins and receptors involved in nervous system diseases and multiple cancers. However, the role of PICK1 in gastric cancer remains unclear. In the present work, we explored the expression and interactions of PICK1 with toll-like receptor 4 (TLR4) in gastric cancer. Clinical data analysis showed that PICK1 expression decreases and is predictive of worse outcomes in patients with gastric cancer. High PICK1 levels attenuated the proliferation and migration of gastric cancer cells, which is dependent on the TLR4/MYD88 signaling pathway. Furthermore, in vitro experiments demonstrated that PICK1 affects the trafficking and degradation of TLR4 and promotes TLR4 degradation via autophagy in gastric cancer cells. Molecular dynamics simulations highlighted the binding strength and stability of the TLR4-PICK1 complex. Our study provides new insights into the cellular and pathological functions of PICK1 in gastric cancer.

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