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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400202


Recent research advances in the biological function and molecular mechanism of methylmalonic acid


Author(s):  Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN

Affiliation(s):  Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; more

Corresponding email(s):   jinjianjun2021@nwafu.edu.cn, lvyuqi@nwafu.edu.cn

Key Words:  Methylmalonic acid, Mitochondrial dysfunction, Oxidative stress, Post-translational modification of proteins, Muscle atrophy


Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN",
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%A Teng WANG
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Abstract: 
The abnormal accumulation of methylmalonic acid (MMA), the leading cause of methylmalonic acidemia, can cause irreversible damage to the brain, kidney and cardiovascular system. In addition, the accumulation of MMA in the blood has recently been associated with the occurrence of cancer, restricted bodily movement and growth retardation. In this review, recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized concerning the brain, kidney, cardiovascular system, cancer, and skeletal muscles, providing a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

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