CLC number: R285.5
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-06-16
Cited: 10
Clicked: 6224
Chun Pang, Yu-chen Sheng, Ping Jiang, Hai Wei, Li-li Ji. Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals[J]. Journal of Zhejiang University Science B, 2015, 16(7): 602-610.
@article{title="Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals",
author="Chun Pang, Yu-chen Sheng, Ping Jiang, Hai Wei, Li-li Ji",
journal="Journal of Zhejiang University Science B",
volume="16",
number="7",
pages="602-610",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400346"
}
%0 Journal Article
%T Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals
%A Chun Pang
%A Yu-chen Sheng
%A Ping Jiang
%A Hai Wei
%A Li-li Ji
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 7
%P 602-610
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400346
TY - JOUR
T1 - Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals
A1 - Chun Pang
A1 - Yu-chen Sheng
A1 - Ping Jiang
A1 - Hai Wei
A1 - Li-li Ji
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 7
SP - 602
EP - 610
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400346
Abstract: chlorogenic acid (CGA), a polyphenolic compound, is abundant in fruits, dietary vegetables, and some medicinal herbs. This study investigated the prevention of CGA against acetaminophen (AP)-induced hepatotoxicity and its engaged mechanisms. CGA reversed the decreased cell viability induced by AP in L-02 cells in vitro. In addition, CGA reduced the AP-induced increased serum levels of alanine/aspartate aminotransferase (ALT/AST) in vivo. The effect of CGA on cytochrome P450 (CYP) enzymatic (CYP2E1, CYP1A2, and CYP3A4) activities showed that CGA caused very little inhibition on CYP2E1 and CYP1A2 enzymatic activities, but not CYP3A4. The measurement of liver malondialdehyde (MDA), reactive oxygen species (ROS), and glutathione (GSH) levels showed that CGA prevented AP-induced liver oxidative stress injury. Further, CGA increased the AP-induced decreased mRNA expression of peroxiredoxin (Prx) 1, 2, 3, 5, 6, epoxide hydrolase (Ephx) 2, and polymerase (RNA) II (DNA directed) polypeptide K (Polr2k), and nuclear factor erythroid-2-related factor 2 (Nrf2). In summary, CGA ameliorates the AP-induced liver injury probably by slightly inhibiting CYP2E1 and CYP1A2 enzymatic properties. In addition, cellular important antioxidant signals such as Prx1, 2, 3, 5, 6, Ephx2, Polr2k, and Nrf2 also contributed to the protection of CGA against AP-induced oxidative stress injury.
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