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Rhein attenuates doxorubicin-induced cardiotoxicity by regulating Drp1-mediated mitochondrial fission via the PI3K/Akt pathway
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Huan YUE1*, Runjing LI3*, Jiajia XU4, Weixin LIU1, Ziyang ZHAO1, Junxiao FENG1, Rui SHI5, Dongkun XIE6, Zhenghao ZHANG2, Xingjuan SHI1. Rhein attenuates doxorubicin-induced cardiotoxicity by regulating Drp1-mediated mitochondrial fission via the PI3K/Akt pathway[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Rhein attenuates doxorubicin-induced cardiotoxicity by regulating Drp1-mediated mitochondrial fission via the PI3K/Akt pathway",
author="Huan YUE1*, Runjing LI3*, Jiajia XU4, Weixin LIU1, Ziyang ZHAO1, Junxiao FENG1, Rui SHI5, Dongkun XIE6, Zhenghao ZHANG2, Xingjuan SHI1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500658"
}
%0 Journal Article
%T Rhein attenuates doxorubicin-induced cardiotoxicity by regulating Drp1-mediated mitochondrial fission via the PI3K/Akt pathway
%A Huan YUE1*
%A Runjing LI3*
%A Jiajia XU4
%A Weixin LIU1
%A Ziyang ZHAO1
%A Junxiao FENG1
%A Rui SHI5
%A Dongkun XIE6
%A Zhenghao ZHANG2
%A Xingjuan SHI1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500658
TY - JOUR
T1 - Rhein attenuates doxorubicin-induced cardiotoxicity by regulating Drp1-mediated mitochondrial fission via the PI3K/Akt pathway
A1 - Huan YUE1*
A1 - Runjing LI3*
A1 - Jiajia XU4
A1 - Weixin LIU1
A1 - Ziyang ZHAO1
A1 - Junxiao FENG1
A1 - Rui SHI5
A1 - Dongkun XIE6
A1 - Zhenghao ZHANG2
A1 - Xingjuan SHI1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500658
Abstract: Mitochondrial dynamics, including mitochondrial fusion and fission, have been identified as a critical regulator of heart function. Doxorubicin (Dox) is a highly effective chemotherapeutic agent that has demonstrated broad-spectrum activity against a variety of tumor types, whereas its application is limited due to cardiotoxic effects. rhein, a medicinal active ingredient found in rhubarb, possesses a wide range of pharmacological activities. However, whether it exerts a cardioprotective role in Dox-induced cardiotoxicity by regulating mitochondrial dynamics remains to be investigated. In this study, we found that Dox treatment promoted mitochondrial fission and elevated the expression of dynamin-related protein 1 (drp1) in cardiomyocytes. In addition, drp1 deletion reduced mitochondrial fission and mitochondrial ROS, and attenuated Dox-induced cardiotoxicity both in vitro and in vivo. Furthermore, rhein treatment rescued Dox-induced cardiac damage in vivo. Mechanistically, rhein attenuated Dox-induced cardiotoxicity by regulating drp1-mediated mitochondrial fission and mitochondrial ROS in cardiomyocytes. Moreover, it alleviated the Dox-induced upregulation of drp1 by activating phosphoinositide 3-kinase (PI3K)/akt signaling pathway. In conclusion, our findings demonstrate that rhein attenuates Dox-induced cardiotoxicity by regulating drp1-mediated mitochondrial fission and mitochondrial ROS via the PI3K/akt pathway.
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