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Journal of Zhejiang University SCIENCE A 2000 Vol.1 No.1 P.27-28

http://doi.org/10.1631/jzus.2000.0027


FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS


Author(s):  CHEN Shao-yuan, YU Yong-ping, GONG Xing-guo, CHEN Yao-zu

Affiliation(s):  Dept. of Biology; more

Corresponding email(s): 

Key Words:  podophyllotoxin, ammonium formate, synthesis


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CHEN Shao-yuan, YU Yong-ping, GONG Xing-guo, CHEN Yao-zu. FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS[J]. Journal of Zhejiang University Science A, 2000, 1(1): 27-28.

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A1 - CHEN Yao-zu
J0 - Journal of Zhejiang University Science A
VL - 1
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DOI - 10.1631/jzus.2000.0027


Abstract: 
4β-amino-4-desoxypodophyllotoxin and 4β-amino-4'-demethyl-4desoxypodophyllo-toxin were synthesized by reduction of the corresponding 4β-azidopodophyllotoxin derivatives with HCO2NH4/Pd-C in excellent yields under convenient and mild reactive condition.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Estape, J., Milla, A., 1982. Review of the clinical activities of VP-16. New Approaches in Cancer Therapy,15:692.

[2]Kuhu, M., Kell,J.C., Von,W.A., 1969. Uber ein neues glykosidierungsverfahhren II. Glykoside des 4'-Demethylepipodophyllotoxins. Helv.Chim.Acta, 52:944.

[3]Lee, K. H., Wang, H. K., 1995. Current status of bioanalysis of etoposide and related compounds. Yaowu Shipin Fenx,3(4):209-32.

[4]Lee, K. H., Cheng, Y. C., Zhang, Y. L., 1995. 4β-amino-podophyllotoxin analogcompounds for treating tumors and methods of synthesis and use. U.S. Patent, US5300,500(Cl. 514-232,5;A61K31/535).

[5]Pan, J. L., Wang, Y. G., Chen, Y. Z., 1997. Synthesis and antitumor activity of new derivatives of podophyllotoxin. Current Sciences,72(4):268.

[6]Siya, R., Richard, E. E., 1988. Ammonium formate in organic synthesis: A versatile agent in catalytic hydrogen transfer reductions. Synthesis, 91 and reference therein 312.

[7]Tian, X., Wang, Y.G., Yang, et al., 1997. Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin. Life Sci. 60: 511.

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