CLC number: R542.21
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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CHEN Peng, ZHOU Jun-fu. CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS[J]. Journal of Zhejiang University Science A, 2001, 2(4): 448-452.
@article{title="CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS",
author="CHEN Peng, ZHOU Jun-fu",
journal="Journal of Zhejiang University Science A",
volume="2",
number="4",
pages="448-452",
year="2001",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2001.0448"
}
%0 Journal Article
%T CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS
%A CHEN Peng
%A ZHOU Jun-fu
%J Journal of Zhejiang University SCIENCE A
%V 2
%N 4
%P 448-452
%@ 1869-1951
%D 2001
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2001.0448
TY - JOUR
T1 - CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS
A1 - CHEN Peng
A1 - ZHOU Jun-fu
J0 - Journal of Zhejiang University Science A
VL - 2
IS - 4
SP - 448
EP - 452
%@ 1869-1951
Y1 - 2001
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2001.0448
Abstract: Objective: To study the changes of oxidative metabolism and lipoperoxidative metabolism in patients with acnte viral myocarditis (AVM), and to research pathological chain reactions of a series of free radicals, and oxidative damage and lipoperoxidative damage in AVM patients' bodies. Methods: A random paired control design was used to investigate 70 cases of AVM patients and 70 cases of healthy adult volunteers (HAV) on the basis of contents of nitric oxide (NO), lipoperoxide (LPO) in plasma, and LPO in red blood cell (RBC) as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC as revealed by spectrophotometric assays. Results: Compared with the average values (AV) of the above biochemical parameters (BP) in the HAV group, the AV of NO in plasma, and LPO in plasma and in RBC in the AVM group were significantly increased (P=0.0001), while the AV of SOD, CAT and GSH-Px in the AVM group were significantly decreased (P=0.0001). Conclusion: The findings in this study suggested that in the AVM patients bodies the metabolism of NO was disturbed, and the pathological chain reactions of a series of free radicals were so severely aggravated, as to cause the oxidative damage and lipoperoxidative damage in the AVM patients' bodies.
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