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Received: 2001-05-06
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SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang. Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport[J]. Journal of Zhejiang University Science A, 2002, 3(4): 475-479.
@article{title="Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport",
author="SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang",
journal="Journal of Zhejiang University Science A",
volume="3",
number="4",
pages="475-479",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0475"
}
%0 Journal Article
%T Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport
%A SHEN Sheng-rong
%A YU Hai-ning
%A JIN Chao-fang
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 4
%P 475-479
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0475
TY - JOUR
T1 - Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport
A1 - SHEN Sheng-rong
A1 - YU Hai-ning
A1 - JIN Chao-fang
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 4
SP - 475
EP - 479
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0475
Abstract: The authors investigated the influence of green tea polyphenols (GTPs) on the liver mitochondria permeability transition pore (PTP) opening through mit ochondria swelling and change of mitochondria membrane potential. The data showed that GTPs had obvious protective effect on the Ca2+-induced PTP opening in a dose-dependent manner detected by mitochondria swelling. The results were obtained by measuring the change of mitochondria membrane potential through Rh 123. Further experiments were conducted to examine the detailed influence of GTPs on Ca2+ import and export of mitochondria. The results showed that GTPs had remarkably inhibitory effect on the Ca2+-induced Ca2+ import in mitochondria; and that they could accelerate Ca2+-release from mitochondria. Our data provide an alternate interpretation of the potent protective function of GTPs on cell against apoptosis.
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