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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.4 P.475-479


Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport

Author(s):  SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang

Affiliation(s):  Department of Tea Sciences, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   shrshen@zju.edu.cn

Key Words:  Mitochondria, PTP green tea polyphenols, mCICR, Ca2+ transport, Mitochondria Δ, Ψ, m

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SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang. Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport[J]. Journal of Zhejiang University Science A, 2002, 3(4): 475-479.

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T1 - Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport
A1 - SHEN Sheng-rong
A1 - YU Hai-ning
A1 - JIN Chao-fang
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DOI - 10.1631/jzus.2002.0475

The authors investigated the influence of green tea polyphenols (GTPs) on the liver mitochondria permeability transition pore (PTP) opening through mit ochondria swelling and change of mitochondria membrane potential. The data showed that GTPs had obvious protective effect on the Ca2+-induced PTP opening in a dose-dependent manner detected by mitochondria swelling. The results were obtained by measuring the change of mitochondria membrane potential through Rh 123. Further experiments were conducted to examine the detailed influence of GTPs on Ca2+ import and export of mitochondria. The results showed that GTPs had remarkably inhibitory effect on the Ca2+-induced Ca2+ import in mitochondria; and that they could accelerate Ca2+-release from mitochondria. Our data provide an alternate interpretation of the potent protective function of GTPs on cell against apoptosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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