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CLC number: R969.2

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Received: 2001-08-06

Revision Accepted: 2002-01-28

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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.4 P.489-492

http://doi.org/10.1631/jzus.2002.0489


Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation


Author(s):  WANG Li-hong, CHEN Jun-zhu, ZHENG Lian-rong, TAO Qian-ming

Affiliation(s):  The First Affiliated Hospital, College of Medicine, Zhejiang University, Hanzhou 310003, China

Corresponding email(s): 

Key Words:  Catheter ablation, Platelet aggregability, Thromboxane B2, Aspirin, Ticlopidine


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WANG Li-hong, CHEN Jun-zhu, ZHENG Lian-rong, TAO Qian-ming. Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation[J]. Journal of Zhejiang University Science A, 2002, 3(4): 489-492.

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author="WANG Li-hong, CHEN Jun-zhu, ZHENG Lian-rong, TAO Qian-ming",
journal="Journal of Zhejiang University Science A",
volume="3",
number="4",
pages="489-492",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0489"
}

%0 Journal Article
%T Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation
%A WANG Li-hong
%A CHEN Jun-zhu
%A ZHENG Lian-rong
%A TAO Qian-ming
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 4
%P 489-492
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0489

TY - JOUR
T1 - Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation
A1 - WANG Li-hong
A1 - CHEN Jun-zhu
A1 - ZHENG Lian-rong
A1 - TAO Qian-ming
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 4
SP - 489
EP - 492
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0489


Abstract: 
Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thromboxane B2 (T XB2) of the blood samples. Patients were divided into aspirin group A, ticlopidine group B, aspirin+ticlopidine group C and control group D. PAG and TXB2 were increased clearly after RFCA in all groups (P<0.001). Treatment with aspirin or ticlopidine before operation could reduce the platelet aggregability caused by RF CA and the joint effect of two drugs (change rate of group A: 52.51±12.51%; group B: 54.78±11.27%; group C: 30.51±10.59%; group D: 91.75±21.43%; P<0.05) was studied. The much decreased platelet aggregability after antiplatelet therapy was evidence of the potential benefit of the treatment in preventing thromboembolism after ablation. Pretreatment with aspirin and ticlopidine together is a good way to decrease palatelet aggregability after RFCA

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Reference

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[3] Manolis, A.S., Maounis, T., Vassilikos, V., Melitamanolis, H., Psarros, L., Terzoglou, G., Cokkinos, V.V., 1998. Pretreatment with antithrombotic agents during radiofrequency catheter ablation: a randomized comparison of aspirin versus ticlopidine. J. Cardiovasc Electrophysiol, 9: 1144-1151.

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