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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.2 P.246-250

http://doi.org/10.1631/jzus.2004.0246


MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms


Author(s):  ZHENG Xu-ning, ZHU Xiong-chao, RUAN Ling-xiang, ZHANG Ling-ju, Yuan Min, SHANG De-sheng, LIU Yang

Affiliation(s):  The first affiliated hospital, College of medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   zhengxn1@mail.hz.zj.cn

Key Words:  Idiopathic Parkinson's disease with unilateral symptom (IPDUS), Magnetic resonance spectroscopy, N-acetyaspartate, Creatine, Choline


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ZHENG Xu-ning, ZHU Xiong-chao, RUAN Ling-xiang, ZHANG Ling-ju, Yuan Min, SHANG De-sheng, LIU Yang. MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms[J]. Journal of Zhejiang University Science A, 2004, 5(2): 246-250.

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author="ZHENG Xu-ning, ZHU Xiong-chao, RUAN Ling-xiang, ZHANG Ling-ju, Yuan Min, SHANG De-sheng, LIU Yang",
journal="Journal of Zhejiang University Science A",
volume="5",
number="2",
pages="246-250",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.0246"
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%T MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms
%A ZHENG Xu-ning
%A ZHU Xiong-chao
%A RUAN Ling-xiang
%A ZHANG Ling-ju
%A Yuan Min
%A SHANG De-sheng
%A LIU Yang
%J Journal of Zhejiang University SCIENCE A
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0246

TY - JOUR
T1 - MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms
A1 - ZHENG Xu-ning
A1 - ZHU Xiong-chao
A1 - RUAN Ling-xiang
A1 - ZHANG Ling-ju
A1 - Yuan Min
A1 - SHANG De-sheng
A1 - LIU Yang
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 246
EP - 250
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0246


Abstract: 
Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P<0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis.

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