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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.4 P.232-235

http://doi.org/10.1631/jzus.2005.B0232


The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation


Author(s):  HONG De-fei, LI Song-ying, TONG Li-min, CHEN Bin, PENG Shu-yong

Affiliation(s):  Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   hongdefi@mail.hz.zj.cn

Key Words:  Hepatic carcinoma/thermotherapy, Laser/diode-laser, Hepatic blood inflow/occlusion


HONG De-fei, LI Song-ying, TONG Li-min, CHEN Bin, PENG Shu-yong. The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation[J]. Journal of Zhejiang University Science B, 2005, 6(4): 232-235.

@article{title="The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation",
author="HONG De-fei, LI Song-ying, TONG Li-min, CHEN Bin, PENG Shu-yong",
journal="Journal of Zhejiang University Science B",
volume="6",
number="4",
pages="232-235",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0232"
}

%0 Journal Article
%T The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation
%A HONG De-fei
%A LI Song-ying
%A TONG Li-min
%A CHEN Bin
%A PENG Shu-yong
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 4
%P 232-235
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0232

TY - JOUR
T1 - The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation
A1 - HONG De-fei
A1 - LI Song-ying
A1 - TONG Li-min
A1 - CHEN Bin
A1 - PENG Shu-yong
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 4
SP - 232
EP - 235
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0232


Abstract: 
Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A received LITT alone; group B received hepatic artery temporary occlusion during LITT; group C received portal vein temporary occlusion during LITT; group D received hepatic artery and portal vein temporary occlusion during LITT. Tumors were exposed to 810 nm diode-laser light at 0.95 watts for 10 min from a scanner tip applicator placed in the tumor. At the same time, the intrahepatic temperature distribution in rats with liver tumors was measured per 2 min during thermocoagulation. Tumor control was examined immediately 7 and 14 d after thermocoagulation. Results: There was significant difference of intrahepatic temperature distribution in rats with liver tumors among the 4 groups (P<0.05) except when group C samples were compared with group D samples at each time point, and group B samples were compared with group C samples at 120 s (P>0.05). Light microscopic examination of the histologic section samples revealed three separate zones: regular hyperthermic coagulation necrosis zone, transition zone and reference zone. Compared with the samples in group A and group B, group C and group D samples had more clear margin among the three zones. Conclusion: The hepatic blood inflow occlusion, especially portal vein hepatic blood inflow occlusion, or all hepatic blood inflow occlusion considerably increased the efficacy of LITT in the treatment of liver cancer.

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Reference

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