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Received: 2005-11-22

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.167-168


Genetics of complex diseases

Author(s):  Motulsky Arno G.

Affiliation(s):  University of Washington, Seattle, WA 98195, USA

Corresponding email(s):   agmot@u.washington.edu

Key Words:  Complex disease, Polymorphisms, Multifactorial inheritance, Monogenic inheritance

Motulsky Arno G.. Genetics of complex diseases[J]. Journal of Zhejiang University Science B, 2006, 7(2): 167-168.

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Approaches to the study of the genetic basis of common complex diseases and their clinical applications are considered. Monogenic Mendelian inheritance in such conditions is infrequent but its elucidation may help to detect pathogenic mechanisms in the more common variety of complex diseases. Involvement by multiple genes in complex diseases usually occurs but the isolation and identification of specific genes so far has been exceptional. The role of common polymorphisms as indicators of disease risk in various studies is discussed.

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[2] Davey Smith, G., Ebrahim, S., Lewis, S., Hansell, A.L., Palmer, L.J., Burton, P.R., 2005. Genetic epidemiology and public health: hope, hype, and future prospects. The Lancet, 366(9495):1484-1498.

[3] Motulsky, A.G., Brunzell, J.D., 2002. Genetics of Coronary Atheroschlerosis. In: The Genetic Basis of Common Diseases, 2nd Ed. Oxford University Press, New York.

[4] Pagon, R.A., 2002. Genetic testing for disease susceptibilities: consequences for genetic counseling. Trends in Molecular Medicine, 8(6):306-307.

[5] Scheuner, M.T., Yoon, P.W., Khoury, M.J., 2004. Contribution of mendelian disorders to common chronic disease: opportunities for recognition, intervention, and prevention. American Journal of Medical Genetics, 125C(l):50-65.

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