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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.8 P.654-659


A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver

Author(s):  XIE Lei, SUN Cai-jun, ZHAO Shi-fang

Affiliation(s):  Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   suncjun@mail.hz.zj.cn

Key Words:  Hyperthermia, Electrothermal needle, Electrochemical therapy, Liver, Rat

XIE Lei, SUN Cai-jun, ZHAO Shi-fang. A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver[J]. Journal of Zhejiang University Science B, 2006, 7(8): 654-659.

@article{title="A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver",
author="XIE Lei, SUN Cai-jun, ZHAO Shi-fang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver
%A XIE Lei
%A SUN Cai-jun
%A ZHAO Shi-fang
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 8
%P 654-659
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0654

T1 - A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver
A1 - XIE Lei
A1 - SUN Cai-jun
A1 - ZHAO Shi-fang
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 8
SP - 654
EP - 659
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0654

Background: electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was increased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Daum, D.R., Smith, N.B., King, R., Hynynen, K., 1999. In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array. Ultrasound Med. Biol., 25(7):1087-1098.

[2] Dong, B., Liang, P., Yu, X., Su, L., Yu, D., Cheng, Z., Zhang, J., 2003. Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am. J. Roentgenol., 180(6):1547-1555.

[3] Gerweck, L.E., Gillette, E.L., Dewey, W.C., 1974. Killing of Chinese hamster cells in vitro by heating under hypoxic or aerobic conditions. Eur. J. Cancer, 10(10):691-693.

[4] Gerweck, L.E., Jennings, M., Richards, B., 1980. Influence of pH on the response of cells to single and split doses of hyperthermia. Cancer Res., 40(11):4019-4024.

[5] Gillams, A.R., Lees, W.R., 2000. Survival after percutaneous, image-guided, thermal ablation of hepatic metastases from colorectal cancer. Dis. Colon Rectum, 43(5):656-661.

[6] Gillams, A.R., Lees, W.R., 2004. Radio-frequency ablation of colorectal liver metastases in 167 patients. Eur. Radiol., 14(12):2261-2267.

[7] Hahn, G.M., Shiu, E.C., 1986. Adaptation to low pH modifies thermal and thermo-chemical responses of mammalian cells. Int. J. Hyperthermia., 2(4):379-387.

[8] Jaak, B., Daniel, S., 1994. Electrochemical aspects of treatment of tissue with direct current. Eur. J. Surg. Suppl., 574:111-115.

[9] Larson, T.R., Rrobertson, D.W., Corica, A., Bostwick, D.G., 2000. In vivo interstitial temperature mapping of the human prostate during cryosurgery with correlation to histopathologic outcomes. Urology, 55(4):547-552.

[10] Nie, Q.H., 2004. Study on dependability between chronic infection of HCV and hepatic cancer. World Chin. J. Digestol., 12(10):2395-2400 (in Chinese).

[11] Nilsson, E., von Euler, H., Berendson, J., Thorne, A., Wersall, P., Naslund, I., Lagerstedt, A.S., Narfstrom, K., Olsson, J.M., 2000. Electrochemical treatment of tumours. Bioelectrochemistry, 51(1):1-11.

[12] Nordenstrom, B.E.W., 1994. Survey of mechanisms in electrochemical treatment (ECT) of cancer. Eur. J. Surg. Suppl., 574:93-109.

[13] Shou, Y.N., Xin, Y.L., Zhao, T.D., Gao, F.Y., 1998. Experimental study of effect of direct electric current combined with hyperthermia on human lung cancer cells. J. Bethune Univ. Med. SCI., 24(5):466-468 (in Chinese).

[14] Sun, C.J. (inventor), 2004. Tumor Electrochemical-Thera-peutic Device Using Electrothermal Needles. US Patent 6,712,840. 2004 Mar. 30.

[15] Sun, C.J., Chen, G.F., 1986. Primary trial of inhibiting effect of electrothermal needles therapy in mice bearing transplantable S180. J. Zhejiang Med. University, 15(3):107-108 (in Chinese).

[16] Sun, C.J., Chen, G.F., 1992. Observation of long term effectiveness of electrothermal needles therapy in the treatment of oral cancers. J. Pract. Oncol., 7:232-341 (in Chinese).

[17] Sun, C.J., Xie, L., 2003. Antitumor effects of electrothermal and electrochemical therapy on mice with Sarcoma180. Zhonghua Kouqiang Yixue Zazhi, 38(5):351-354 (in Chinese).

[18] von Euler, H., Nilsson, E., Olsson, J.M., Lagerstedt, A.S., 2001. Electrochemical treatment (EChT) effects in rat mammary and liver tissue. In vivo optimizing of a dose-planning model for EChT of tumors. Bioelectrochemistry, 54(2):117-124.

[19] Wang, L.D., Shi, S.T., Zhou, Q., Goldstein, S., Hong, J.Y., Shao, P., Qiu, S.L., Yang, C.S., 1994. Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis. Int. J. Cancer, 59(4):514-519.

[20] Wemyss-Holden, S.A., Dennison, A.R., Berry, D.P., Maddern, G.J., 2004. Local ablation for unresectable liver tumor: is thermal best? Journal of Hepato-Biliary-Pancreatic Surgery, 11(2):97-106.

[21] Xin, Y., 1994. Organisation and spread of electrochemical therapy in China. Eur. J. Surg. Suppl., 574:25-29.

[22] Ye, S.L., 2002. Present status and evaluation of interventional therapy for primary hepatocellular carcinoma. Chinese Journal of Hepatology, 3(10):165-166 (in Chinese).

[23] Ye, S.L., 2004. Emphasis on standard treatment for primary hepatocellular carcinoma. Chinese Journal of Hepatology, 8(13):449-450 (in Chinese).

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