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On-line Access: 2016-11-03

Received: 2016-03-03

Revision Accepted: 2016-05-14

Crosschecked: 2016-10-10

Cited: 6

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Yang Guo


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.11 P.831-841


Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis

Author(s):  Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   mavis199005@zju.edu.cn, cxiang@zju.edu.cn

Key Words:  Liver fibrosis, Cell therapy, Mesenchymal stem cells

Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang. Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis[J]. Journal of Zhejiang University Science B, 2016, 17(11): 831-841.

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%T Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis
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T1 - Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis
A1 - Yang Guo
A1 - Bo Chen
A1 - Li-jun Chen
A1 - Chun-feng Zhang
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J0 - Journal of Zhejiang University Science B
VL - 17
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600101

liver fibrosis is the end-stage of many chronic liver diseases and is a significant health threat. The only effective therapy is liver transplantation, which still has many problems, including the lack of donor sources, immunological rejection, and high surgery costs, among others. However, the use of cell therapy is becoming more prevalent, and mesenchymal stem cells (MSCs) seem to be a promising cell type for the treatment of liver fibrosis. MSCs have multiple differentiation abilities, allowing them to migrate directly into injured tissue and differentiate into hepatocyte-like cells. Additionally, MSCs can release various growth factors and cytokines to increase hepatocyte regeneration, regress liver fibrosis, and regulate inflammation and immune responses. In this review, we summarize the current uses of MSC therapies for liver fibrosis and suggest potential future applications.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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