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Received: 2005-11-17

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.8 P.654-659


A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver

Author(s):  XIE Lei, SUN Cai-jun, ZHAO Shi-fang

Affiliation(s):  Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   suncjun@mail.hz.zj.cn

Key Words:  Hyperthermia, Electrothermal needle, Electrochemical therapy, Liver, Rat

XIE Lei, SUN Cai-jun, ZHAO Shi-fang. A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver[J]. Journal of Zhejiang University Science B, 2006, 7(8): 654-659.

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author="XIE Lei, SUN Cai-jun, ZHAO Shi-fang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver
%A XIE Lei
%A SUN Cai-jun
%A ZHAO Shi-fang
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 8
%P 654-659
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0654

T1 - A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver
A1 - XIE Lei
A1 - SUN Cai-jun
A1 - ZHAO Shi-fang
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 8
SP - 654
EP - 659
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0654

Background: electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was increased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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