CLC number: R54
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 1
Clicked: 5905
LI Nan, WANG Jian-an. Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?[J]. Journal of Zhejiang University Science B, 2006, 7(9): 766-768.
@article{title="Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?",
author="LI Nan, WANG Jian-an",
journal="Journal of Zhejiang University Science B",
volume="7",
number="9",
pages="766-768",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0766"
}
%0 Journal Article
%T Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?
%A LI Nan
%A WANG Jian-an
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 9
%P 766-768
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0766
TY - JOUR
T1 - Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?
A1 - LI Nan
A1 - WANG Jian-an
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 9
SP - 766
EP - 768
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0766
Abstract: We observed in a pilot study that there was a transient elevation of brain natriuretic peptide (BNP) level shortly after the transplantation in the patient with ischemic heart failure, which is unexplainable by the simultaneous increase of the cardiac output and six-minute walk distance. Similar findings were observed in the phase I trial. We postulated on the basis of the finding of Fukuda in vitro that this transient elevation of BNP level against the improvement of cardiac function and exercise capacity might indicate cardiomyogenesis in patients after mesenchymal stem cell transplantation. Further study is warranted to verify the hypothesis.
[1] Dai, W.D., Hale, S.L., Martin, B.J., Kuang, J.Q., Dow, J.S., Wold, L.E., Kloner, R.A., 2005. Allogenic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation, 112(2):214-223.
[2] Dick, A.J., Guttman, M.A., Raman, V.K., Peters, D.C., Pessanha, B.S., Hill, J.M., Smith, S., Scott, G., McVeigh, E.R., Lederman, R.J., 2003. Magnetic resonance fluoroscopy allows targeted delivery of mesenchymal stem cells to infarct borders in Swine. Circulation, 108(23):2899-2904.
[3] Fukuda, K., 2002. Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes. C. R. Biol., 325(10):1027-1038.
[4] Li, N., Wang, J.A., 2005. Brain natriuretic peptide and optimal management of heart failure. J. Zhejiang Univ. SCIENCE, 6B(9):877-884.
[5] Pittenger, M.F., Martin, B.J., 2004. Mesenchymal stem cells and their potential as cardiac therapeutics. Circulation Research, 95(1):9.
[6] Shake, J.G., Gruber, P.J., Baumgartner, W.A., Senechal, G., Meyers, J., Redmond, J.M., Pittenger, M.F., Martin, B.J., 2002. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann. Thorac. Surg., 73(6):1919-1926.
[7] Tang, Y.L., Zhao, Q., Zhang, Y.C., Cheng, L., Liu, M., Shi, J., Yang, Y.Z., Pan, C., Ge, J., Phillips, M.I., 2004. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul. Pept., 117(1):3-10.
[8] Wang, J.A., Li, C.L., Fan, Y.Q., He, H., Sun, Y., 2004. Allograft bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart. J. Zhejiang Univ. SCIENCE, 5(10):1279-1285.
Open peer comments: Debate/Discuss/Question/Opinion
<1>