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On-line Access: 2023-02-05

Received: 2022-08-21

Revision Accepted: 2022-10-26

Crosschecked: 2023-02-09

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Yuntao WANG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.2 P.115-129


Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway

Author(s):  Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yuao TAO, Xiaolong LI, Xi LI, Yuntao WANG

Affiliation(s):  Medical School of Southeast University, Southeast University,Nanjing210009,China; more

Corresponding email(s):   wangyttodd@163.com

Key Words:  Mesenchymal stem cells (MSCs), Ferroptosis, Oxidative stress (OS), Iron metabolism, Lipid peroxidation, Glutathione peroxidase 4 (GPX4)

Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yuao TAO, Xiaolong LI, Xi LI, Yuntao WANG. Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway[J]. Journal of Zhejiang University Science B, 2023, 24(2): 115-129.

@article{title="Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway",
author="Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yuao TAO, Xiaolong LI, Xi LI, Yuntao WANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway
%A Yuzhu XU
%A Pan FAN
%A Lei LIU
%A Xuanfei XU
%A Jiadong WANG
%A Yuao TAO
%A Xiaolong LI
%A Xi LI
%A Yuntao WANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 2
%P 115-129
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200410

T1 - Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway
A1 - Yuzhu XU
A1 - Pan FAN
A1 - Lei LIU
A1 - Xuanfei XU
A1 - Lele ZHANG
A1 - Jiadong WANG
A1 - Yuao TAO
A1 - Xiaolong LI
A1 - Xi LI
A1 - Yuntao WANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 2
SP - 115
EP - 129
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200410

Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells, but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period. Hence, strategies to increase the efficacy of MSC treatment are urgently needed. Iron overload, reactive oxygen species deposition, and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs, thereby hastening cell death. Notably, oxidative stress (OS) and deficient antioxidant defense induced by iron overload can result in ferroptosis. ferroptosis may inhibit cell survival after MSC transplantation, thereby reducing clinical efficacy. In this review, we explore the role of ferroptosis in MSC performance. Given that little research has focused on ferroptosis in transplanted MSCs, further study is urgently needed to enhance the in vivo implantation, function, and duration of MSCs.



关键词:间充质干细胞(MSCs);铁死亡;氧化应激(OS);铁代谢途径;脂质过氧化; 谷胱甘肽过氧化物酶4(GPX4)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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