Full Text:   <2950>

CLC number: R541.4

On-line Access: 2013-07-30

Received: 2012-11-08

Revision Accepted: 2013-05-03

Crosschecked: 2013-07-19

Cited: 5

Clicked: 5307

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.736-742

http://doi.org/10.1631/jzus.B1200306


Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage


Author(s):  Geng Qian, Hong-bin Liu, Jin-wen Wang, Chen Wu, Yun-dai Chen

Affiliation(s):  Department of Cardiology, Chinese Peoples Liberation Army General Hospital, Beijing 100853, China

Corresponding email(s):   qiangeng9396@263.net, cyundai@126.com

Key Words:  Acute myocardial infarction (AMI), Risk factor, Hemorrhage


Geng Qian, Hong-bin Liu, Jin-wen Wang, Chen Wu, Yun-dai Chen. Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage[J]. Journal of Zhejiang University Science B, 2013, 14(8): 736-742.

@article{title="Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage",
author="Geng Qian, Hong-bin Liu, Jin-wen Wang, Chen Wu, Yun-dai Chen",
journal="Journal of Zhejiang University Science B",
volume="14",
number="8",
pages="736-742",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200306"
}

%0 Journal Article
%T Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage
%A Geng Qian
%A Hong-bin Liu
%A Jin-wen Wang
%A Chen Wu
%A Yun-dai Chen
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 8
%P 736-742
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200306

TY - JOUR
T1 - Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage
A1 - Geng Qian
A1 - Hong-bin Liu
A1 - Jin-wen Wang
A1 - Chen Wu
A1 - Yun-dai Chen
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 8
SP - 736
EP - 742
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200306


Abstract: 
Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of 10202 consecutive AMI patients were recruited, and mechanical complications occurred in 72 patients. AMI patients without CR were chosen as control group. Clinical characteristics including bleeding-related factors were compared between the groups. The incidences of free wall rupture (FWR), ventricular septal rupture (VSR), and papillary muscle rupture (PMR) were 0.39%, 0.21%, and 0.09%, respectively, and the hospital mortalities were 92.5%, 45.5%, and 10.0%, respectively. Female proportion and average age were significantly higher in the groups of FWR and VSR than in the control group (P<0.01); higher white blood cell count and lower hemoglobin were found in all CR groups (P<0.01). Compared to the control group, patients with CR were more likely to receive an administration of thrombolysis [26.39% vs. 13.19%, P<0.05], and were less likely to be treated with primary percutaneous coronary intervention (PCI) [41.67% vs. 81.60%, P<0.05]. The major bleeding scores (integer scores) of FWR, VSR, and PMR were (17.70±7.24), (21.91±8.33), and (18.60±7.88), respectively, and were significantly higher than that of the control group (11.72±7.71) (P<0.05). A regression analysis identified age, increased heart rate, anemia, higher white blood cell count, and thrombolysis as independent risk factors of CR, most of which were major bleeding-related factors. The patients with CR have a significantly higher risk of hemorrhage compared to the group without CR. Risk of CR after AMI is related to the risk of hemorrhage.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Altunkeser, B.B., Özdemir, K., Özdemir, A., Gök, H., 2002. A subacute left ventricular free wall rupture after thrombolytic and glycoprotein IIb/IIIa inhibitor treatment: an overlooked finding of left ventriculography. Jpn. Heart J., 43(3):289-293.

[2]Bueno, H., Martinez-Selles, M., Perez-David, E., López-Palop, R., 2005. Effect of thrombolytic therapy on the risk of cardiac rupture and mortality in older patients with first acute myocardial infarction. Eur. Heart J., 26(17):1705-1711.

[3]Dhand, A., Nakagawa, K., Nagpal, S., Gelfand, J.M., Kim, A.S., Smith, W.S., Tihan, T., 2010. Cardiac rupture after intravenous t-PA administration in acute ischemic stroke. Neurocrit. Care, 13(2):261-262.

[4]Fang, L., Gao, X.M., Moore, X.L., Kiriazis, H., Su, Y., Ming, Z., Lim, Y.L., Dart, A.M., Du, X.J., 2007. Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J. Mol. Cell Cardiol., 43(5):535-544.

[5]Fang, L., Gao, X.M., Samuel, C.S., Su, Y., Lim, Y.L., Dart, A.M., Du, X.J., 2008. Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction. Clin. Sci. (Lond.), 115(3):99-106.

[6]Figueras, J., Alcalde, O., Barrabes, J.A., Serra, V., Alguersuari, J., Cortadellas, J., Lidon, R.M., 2008. Changes in hospital mortality rates in 425 patients with acute ST-elevation myocardial infarction and cardiac rupture over a 30-year period. Circulation, 118(25):2783-2789.

[7]Figueras, J., Barrabes, J.A., Serra, V., Cortadellas, J., Lidon, R.M., Carrizo, A., Garcia-Dorado, D., 2010. Hospital outcome of moderate to severe pericardial effusion complicating ST-elevation acute myocardial infarction. Circulation, 122(19):1902-1909.

[8]French, J.K., Hellkamp, A.S., Armstrong, P.W., Cohen, E., Kleiman, N.S., O′Connor, C.M., Holmes, D.R., Hochman, J.S., Granger, C.B., Mahaffey, K.W., 2010. Mechanical complications after percutaneous coronary intervention in ST-elevation myocardial infarction (from APEX-AMI). Am. J. Cardiol., 105(1):59-63.

[9]Gao, R.L., Han, Y.L., Yang, X.C., Mao, J.M., Fang, W.Y., Wang, L., Shen, W.F., Li, Z.Q., Jia, G.L., Lv, S.Z., et al., 2010. Thorombolytic therapy with rescue percutaneous coronary intervention versus primary percutaneous coronary intervention in patients with acute myocardial infarction: a multicenter randomized clinical trial. Chin. Med. J. (Engl.), 123(11):1365-1372.

[10]Gao, X.M., Ming, Z., Su, Y., Fang, L., Kiriazis, H., Xu, Q., Dart, A.M., Du, X.J., 2010. Infarct size and post-infarct inflammation determine the risk of cardiac rupture in mice. Int. J. Cardiol., 143(1):20-28.

[11]Haddadin, S., Milano, A.D., Faggian, G., Morjan, M., Patelli, F., Golia, G., Franchi, P., Mazzucco, A., 2009. Surgical treatment of postinfarction left ventricular free wall rupture. J. Card. Surg., 24(6):624-631.

[12]Kameda, K., Matsunaga, T., Abe, N., Fujiwara, T., Hanada, H., Fukui, K., Fukuda, I., Osanai, T., Okumura, K., 2006. Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture. Circ. J., 70(6):673-678.

[13]Kushner, F.G., Hand, M., Smith, S.C.Jr., King, S.B.3rd, Anderson, J.L., Antman, E.M., Bailey, S.R., Bates, E.R., Blankenship, J.C., Casey, D.E.Jr., et al., 2009. 2009 focused updates: ACC/AHA Guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 Guideline and 2007 focused update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (updating the 2005 Guideline and 2007 focused update): A report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Circulation, 120(22):2271-2306.

[14]López-Sendón, J., Gurfinkel, E.P., de Sa, E.L., Agnelli, G., Gore, J.M., Steg, P.G., Eagle, K.A., Cantador, J.R., Fitzgerald, G., Granger, C.B., et al., 2010. Factors related to heart rupture in acute coronary syndromes in the global registry of acute coronary events. Eur. Heart J., 31(12):1449-1456.

[15]Markowicz-Pawlus, E., Nozynski, J., Sedkowska, A., Jarski, P., Hawranek, M., Streb, W., Zielinska, T., Polonski, L., Kalarus, Z., 2007. Cardiac rupture risk estimation in patients with acute myocardial infarction treated with percutaneous coronary intervention. Cardiol. J., 14(6):538-543.

[16]Mehran, R., Pocock, S.J., Nikolsky, E., Clayton, T., Dangas, G.D., Kirtane, A.J., Parise, H., Fahy, M., Manoukian, S.V., Feit, F., et al., 2010. A risk score to predict bleeding in patients with acute coronary syndromes. J. Am. Coll. Cardiol., 55(23):2556-2566.

[17]Okino, S., Nishiyama, K., Ando, K., Nobuyoshi, M., 2005. Thrombolysis increases the risk of free wall rupture in patients with acute myocardial infarction undergoing percutaneous coronary intervention. J. Interv. Cardiol., 18(3):167-172.

[18]Pedrazzini, G., Santoro, E., Latini, R., Fromm, L., Franzosi, M.G., Mocetti, T., Staszewsky, L., Barlera, S., Tognoni, G., Maggioni, A.P., et al., 2008. Causes of death in patients with acute myocardial infarction treated with angiotensin-converting enzyme inhibitors: findings from the Gruppo Italiano per Lo Studio della Sopravvivenza nell’Infarto (GISSI)-3 trial. Am. Heart J., 155(2):388-394.

[19]Qian, G., Wang, Z.F., Liu, H.B., Chen, Y.D., 2011. Clinical manifestations of 43 patients with acute myocardial infarction complicated by free wall rupture. Chin. J. Cardiol., 39(9):812-815 (in Chinese).

[20]Sakaguchi, G., Komiya, T., Tamura, N., Kobayashi, T., 2008. Surgical treatment for postinfarction left ventricular free wall rupture. Ann. Thorac. Surg., 85(4):1344-1346.

[21]Sane, D.C., Mozingo, W.S., Becker, R.C., 2009. Cardiac rupture after myocardial infarction: new insights from murine models. Cardiol. Rev., 17(6):293-299.

[22]Subherwal, S., Bach, R.G., Chen, A.Y., Gage, B.F., Rao, S.V., Newby, L.K., Wang, T.Y., Gibler, W.B., Ohman, E.M., Roe, M.T., et al., 2009. Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction. The CRUSADE (can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA Guidelines) bleeding score. Circulation, 119(14):1873-1882.

[23]van de Werf, F., Bax, J., Betriu, A., Blomstrom-Lundqvist, C., Crea, F., Falk, V., Filippatos, G., Fox, K., Huber, K., Kastrati, A., et al., 2008. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the european society of cardiology. Eur. Heart J., 29(23):2909-2945.

[24]Yip, H.K., Wu, C.J., Chang, H.W., Wang, C.P., Cheng, C.I., Chua, S., Chen, M.C., 2003. Cardiac rupture complicating acute myocardial infarction in the direct percutaneous coronary intervention reperfusion era. Chest, 124(2):565-571.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE