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Received: 2007-04-08

Revision Accepted: 2007-07-23

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.9 P.638-646


Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients


Affiliation(s):  Division of Human Genetics, Department of Zoology, Bharathiar University, Coimbatore-641046, Tamilnadu, India

Corresponding email(s):   geneticbala@yahoo.co.in

Key Words:  Prostate cancer, Chromosomal aberrations (CA), Giemsa-banding, Spectral karyotyping (SKY)

BALACHANDAR V., LAKSHMAN KUMAR B., SASIKALA K., MANIKANTAN P., SANGEETHA R., MOHANA DEVI S.. Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients[J]. Journal of Zhejiang University Science B, 2007, 8(9): 638-646.

@article{title="Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0638

T1 - Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients
J0 - Journal of Zhejiang University Science B
VL - 8
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SP - 638
EP - 646
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2007.B0638

The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in prostate cancer patients of Tamilnadu, Southern India. Totally 45 blood samples were collected from various hospitals in Tamilnadu, Southern India. Equal numbers of normal healthy subjects were chosen after signing a consent form. Volunteers provided blood samples (5 ml) to establish leukocyte cultures. Cytogenetic studies were performed by using giemsa-banding technique and finally the results were ensured by spectral karyotyping (SKY) technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identified in experimental subjects. Results showed frequent CA in chromosomes 1, 3, 5, 6, 7, 9, 13, 16, 18 and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA (P<0.05). In the present study, the high frequency of centromeric rearrangements indicates a potential role for mitotic irregularities associated with the centromere in prostate cancer tumorigenesis. Identification of chromosome alterations may be helpful in understanding the molecular basis of the disease in better manner.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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