CLC number: Q2; R5
On-line Access: 2024-08-27
Received: 2023-10-17
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Rui-wei GUO, Lan HUANG. New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai[J]. Journal of Zhejiang University Science B, 2008, 9(8): 591-601.
@article{title="New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai",
author="Rui-wei GUO, Lan HUANG",
journal="Journal of Zhejiang University Science B",
volume="9",
number="8",
pages="591-601",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820042"
}
%0 Journal Article
%T New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai
%A Rui-wei GUO
%A Lan HUANG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 8
%P 591-601
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820042
TY - JOUR
T1 - New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai
A1 - Rui-wei GUO
A1 - Lan HUANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 8
SP - 591
EP - 601
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820042
Abstract: The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).
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