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Crosschecked: 2009-01-19

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.3 P.237-241

http://doi.org/10.1631/jzus.B0820172


Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature


Author(s):  Li-duan ZHENG, Xiu-ping YANG, Hua-xiong PAN, Xiu NIE, Jun HE, Qing LV, Qiang-song TONG

Affiliation(s):  Department of Pathology; more

Corresponding email(s):   qs_tong@hotmail.com

Key Words:  Gastric carcinoma, Adenocarcinoma, Osteoclast-like giant cell (OGC)


Li-duan ZHENG, Xiu-ping YANG, Hua-xiong PAN, Xiu NIE, Jun HE, Qing LV, Qiang-song TONG. Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature[J]. Journal of Zhejiang University Science B, 2009, 10(3): 237-241.

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author="Li-duan ZHENG, Xiu-ping YANG, Hua-xiong PAN, Xiu NIE, Jun HE, Qing LV, Qiang-song TONG",
journal="Journal of Zhejiang University Science B",
volume="10",
number="3",
pages="237-241",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820172"
}

%0 Journal Article
%T Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature
%A Li-duan ZHENG
%A Xiu-ping YANG
%A Hua-xiong PAN
%A Xiu NIE
%A Jun HE
%A Qing LV
%A Qiang-song TONG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 3
%P 237-241
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820172

TY - JOUR
T1 - Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature
A1 - Li-duan ZHENG
A1 - Xiu-ping YANG
A1 - Hua-xiong PAN
A1 - Xiu NIE
A1 - Jun HE
A1 - Qing LV
A1 - Qiang-song TONG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 3
SP - 237
EP - 241
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820172


Abstract: 
gastric carcinoma with osteoclast-like giant cells (OGCs) is an extremely rare tumor. So far, only six cases have been reported in the literature. Here we report an additional case of this tumor in a Chinese 78-year-old man presented with abdominal pain, vomiting, and hematemesis. Physical examination and gastroscopy revealed a tumor in the gastric antrum. The biopsy and pathological findings indicated a gastric adenocarcinoma with OGCs, which were present in both the tumor and the metastatic lymph nodes. Further immunohistochemical staining indicated that OGCs were reactive with CD68, CD45, and vimentin protein, but not with pancytokeratin, carcinoembryonic antigen, or epithelial membrane antigen, suggesting the monocytic/histiocytic derivation of these OGCs. In situ hybridization for Epstein-Barr virus showed no nuclear positivity in either adenocarcinoma or OGCs. Postoperative follow-up showed that the patient had survived for at least 6 months without recurrence. Further investigation is warranted to clearly define the prognostic significance of OGCs in gastric carcinoma.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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