CLC number: R735
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2009-01-19
Cited: 7
Clicked: 6878
Li-duan ZHENG, Xiu-ping YANG, Hua-xiong PAN, Xiu NIE, Jun HE, Qing LV, Qiang-song TONG. Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature[J]. Journal of Zhejiang University Science B, 2009, 10(3): 237-241.
@article{title="Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature",
author="Li-duan ZHENG, Xiu-ping YANG, Hua-xiong PAN, Xiu NIE, Jun HE, Qing LV, Qiang-song TONG",
journal="Journal of Zhejiang University Science B",
volume="10",
number="3",
pages="237-241",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820172"
}
%0 Journal Article
%T Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature
%A Li-duan ZHENG
%A Xiu-ping YANG
%A Hua-xiong PAN
%A Xiu NIE
%A Jun HE
%A Qing LV
%A Qiang-song TONG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 3
%P 237-241
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820172
TY - JOUR
T1 - Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature
A1 - Li-duan ZHENG
A1 - Xiu-ping YANG
A1 - Hua-xiong PAN
A1 - Xiu NIE
A1 - Jun HE
A1 - Qing LV
A1 - Qiang-song TONG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 3
SP - 237
EP - 241
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820172
Abstract: gastric carcinoma with osteoclast-like giant cells (OGCs) is an extremely rare tumor. So far, only six cases have been reported in the literature. Here we report an additional case of this tumor in a Chinese 78-year-old man presented with abdominal pain, vomiting, and hematemesis. Physical examination and gastroscopy revealed a tumor in the gastric antrum. The biopsy and pathological findings indicated a gastric adenocarcinoma with OGCs, which were present in both the tumor and the metastatic lymph nodes. Further immunohistochemical staining indicated that OGCs were reactive with CD68, CD45, and vimentin protein, but not with pancytokeratin, carcinoembryonic antigen, or epithelial membrane antigen, suggesting the monocytic/histiocytic derivation of these OGCs. In situ hybridization for Epstein-Barr virus showed no nuclear positivity in either adenocarcinoma or OGCs. Postoperative follow-up showed that the patient had survived for at least 6 months without recurrence. Further investigation is warranted to clearly define the prognostic significance of OGCs in gastric carcinoma.
[1] Ahaouche, M., Cazals-Hatem, D., Sommacale, D., Cadranel, J.F., Belghiti, J., Degott, C., 2005. A malignant hepatic tumour with osteoclast-like giant cells. Histopathology, 46(5):590-592.
[2] Akatsu, T., Kameyama, K., Kawachi, S., Tanabe, M., Aiura, K., Wakabayashi, G., Ueda, M., Shimazu, M., Kitajima, M., 2006. Gallbladder carcinoma with osteoclast-like giant cells. J. Gastroenterol., 41(1):83-87.
[3] Alasio, T.M., Sun, W., Yang, G.C., 2007. Giant cell carcinoma of the lung impact of diagnosis and review of cytological features. Diagn. Cytopathol., 35(9):555-559.
[4] Al-Brahim, N., Salama, S., 2005. Malignant melanoma with osteoclast-like giant cells: an unusual host response: immunohistochemical and ultrastructural study of three cases and literature review. Am. J. Dermatopathol., 27(2):126-129.
[5] Baschinsky, D.Y., Frankel, W.L., Niemann, T.H., 1999. Gastric carcinoma with osteoclast-like giant cells. Am. J. Gastroenterol., 94(6):1678-1681.
[6] Bocklage, T.J., Dail, D., Colby, T.V., 1998. Primary lung tumors infiltrated by osteoclast-like giant cells. Ann. Diagn. Pathol., 2(4):229-240.
[7] Gjerdrum, L.M., Lauridsen, M.C., Sorensen, F.B., 2001. Breast carcinoma with osteoclast-like giant cells: morphological and ultrastructural studies of a case with review of the literature. Breast, 10(3):231-236.
[8] Krishnan, C., Longacre, T.A., 2006. Ductal carcinoma in situ of the breast with osteoclast-like giant cells. Hum. Pathol., 37(3):369-372.
[9] Mehdi, G., Ansari, H.A., Siddiqui, S.A., 2007. Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells—a case report. Diagn. Cytopathol., 35(2):111-112.
[10] Min, K.W., Gillies, E., 1996. Multinucleated giant stromal tumor of the omentum: report of a case with immunohistochemical and ultrastructural investigation. Ultrastruct. Pathol., 20(1):89-99.
[11] Molberg, K.H., Heffess, C., Delgado, R., Albores-Saavedra, J., 1998. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer, 82(7):1279-1287.
[12] Newbould, M.J., Benbow, E.W., Sene, A., Young, M., Taylor, T.V., 1992. Adenocarcinoma of the pancreas with osteoclast-like giant cells: a case report with immunocytochemistry. Pancreas, 7(5):611-615.
[13] Shibata, D., Tokunaga, M., Uemura, Y., Sato, E., Tanaka, S., Weiss, L.M., 1991. Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. Am. J. Pathol., 139(3):469-474.
[14] Stracca-Pansa, V., Menegon, A., Donisi, P.M., Bozzola, L., Fedeli, F., Quarto, F., Nappi, O., Pettinato, G., 1995. Gastric carcinoma with osteoclast-like giant cells. Report of four cases. Am. J. Clin. Pathol., 103(4):453-459.
[15] Tezuka, K., Yamakawa, M., Jingu, A., Ikeda, Y., Kimura, W., 2006. An unusual case of undifferentiated carcinoma in situ with osteoclast-like giant cells of the pancreas. Pancreas, 33(3):304-310.
[16] Willems, S., Carneiro, F., Geboes, K., 2005. Gastric carcinoma with osteoclast-like giant cells and lymphoepithelioma-like carcinoma of the stomach: two of a kind? Histopathology, 47(3):331-333.
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