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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.4 P.317-322

http://doi.org/10.1631/jzus.B0820316


Anticonvulsant and hypnotic effects of amiodarone


Author(s):  Gunnur OZBAKIS-DENGIZ, Aysegul BAKIRCI

Affiliation(s):  Department of Pharmacology, Medical Faculty, Karaelmas University, 67 600 Zonguldak, Turkey; more

Corresponding email(s):   gunnurozbakis@mynet.com, aysegulbakirci@mynet.com

Key Words:  Amiodarone, Phentylenetetrazole (PTZ), Caffeine, Convulsion, Sleeping


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Gunnur OZBAKIS-DENGIZ, Aysegul BAKIRCI. Anticonvulsant and hypnotic effects of amiodarone[J]. Journal of Zhejiang University Science B, 2009, 10(4): 317-322.

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author="Gunnur OZBAKIS-DENGIZ, Aysegul BAKIRCI",
journal="Journal of Zhejiang University Science B",
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doi="10.1631/jzus.B0820316"
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DOI - 10.1631/jzus.B0820316


Abstract: 
amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. amiodarone dose-dependently increased the sleeping time (677.7%~725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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