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Received: 2009-10-30

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.4 P.286-291


Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.

Author(s):  Hao Yin, Xin-qin Shi, Bo Sun, Jing-jing Ye, Zu-an Duan, Xiao-ling Zhou, Wei-zheng Cui, Xiao-feng Wu

Affiliation(s):  Key Laboratory of Agricultural Ecology and Environment, College of Forestry, Shandong Agricultural University, Taian 271018, China, Institute of Sericultural Sciences of Sichuan Province, Nanchong 637000, China, College of Animal Science, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   wzcui88@163.com, wuxiaofeng@zju.edu.cn

Key Words:  Silkworm, 1-deoxynojirimycin (1-DNJ), Accumulation, Bombyx mori

Hao Yin, Xin-qin Shi, Bo Sun, Jing-jing Ye, Zu-an Duan, Xiao-ling Zhou, Wei-zheng Cui, Xiao-feng Wu. Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.[J]. Journal of Zhejiang University Science B, 2010, 11(4): 286-291.

@article{title="Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.",
author="Hao Yin, Xin-qin Shi, Bo Sun, Jing-jing Ye, Zu-an Duan, Xiao-ling Zhou, Wei-zheng Cui, Xiao-feng Wu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.
%A Hao Yin
%A Xin-qin Shi
%A Bo Sun
%A Jing-jing Ye
%A Zu-an Duan
%A Xiao-ling Zhou
%A Wei-zheng Cui
%A Xiao-feng Wu
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 4
%P 286-291
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900344

T1 - Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.
A1 - Hao Yin
A1 - Xin-qin Shi
A1 - Bo Sun
A1 - Jing-jing Ye
A1 - Zu-an Duan
A1 - Xiao-ling Zhou
A1 - Wei-zheng Cui
A1 - Xiao-feng Wu
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 4
SP - 286
EP - 291
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900344

1-deoxynojirimycin (1-DNJ) contents in the silkworm, Bombyx mori, at different developmental stages and tissues were investigated by using reverse-phase high-performance liquid chromatography. The 1-DNJ contents of silkworm larvae change significantly with their developmental stages. The male larvae showed higher accumulation efficiency of 1-DNJ than the females and also a significant variation was observed among the silkworm strains. The present results show that tissue distribution of 1-DNJ was significantly higher in blood, digestive juice, and alimentary canal, but no 1-DNJ was observed in the silkgland. Moreover, 1-DNJ was not found in silkworms fed with artificial diet that does not contain mulberry leaf powder. This proves that silkworms obtain 1-DNJ from mulberry leaves; they could not synthesize 1-DNJ by themselves. The accumulation and excretion of 1-DNJ change periodically during the larval stage. There was no 1-DNJ in the newly-hatched larvae and 1-DNJ was mainly accumulated during the early and middle stages of every instar, while excreted at later stages of larval development. Further, it is possible to extract 1-DNJ from the larval feces and it is optimal to develop the 1-DNJ related products for diabetic auxiliary therapy.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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