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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.11 P.791-795


Decreased serum prohepcidin concentration in patients with polycythemia vera

Author(s):  Justyna KWAPISZ, Ewa Ż,EKANOWSKA, Joanna JASINIEWSKA

Affiliation(s):  Department of Pathophysiology, Nicolaus Copernicus University in Toruń more

Corresponding email(s):   justyna.kwapisz@gmail.com

Key Words:  Polycythemia vera (PV), Iron metabolism, Prohepcidin, Hepcidin

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Justyna KWAPISZ, Ewa ŻEKANOWSKA, Joanna JASINIEWSKA. Decreased serum prohepcidin concentration in patients with polycythemia vera[J]. Journal of Zhejiang University Science B, 2009, 10(11): 791-795.

@article{title="Decreased serum prohepcidin concentration in patients with polycythemia vera",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Decreased serum prohepcidin concentration in patients with polycythemia vera
%A Justyna KWAPISZ
%A Ewa Ż
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 11
%P 791-795
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920217

T1 - Decreased serum prohepcidin concentration in patients with polycythemia vera
A1 - Justyna KWAPISZ
A1 - Ewa Ż
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 11
SP - 791
EP - 795
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0920217

Objective: Iron deficiency is a common complication in patients with polycythemia vera (PV). hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess hepcidin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prohepcidin, a hepcidin precursor, and other iron status parameters in the serum of PV patients. Methods: The study was performed in 60 patients (F/M 26/34) aged 38~84 (66±10) years. The control group consisted of 20 healthy volunteers, age and sex matched. The following parameters were determined in blood serum samples: hepcidin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prohepcidin concentration, iron content, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), transferrin saturation (TfS), and concentrations of ferritin and soluble transferrin receptor (sTfR). Results: All PV patients showed significantly lower levels of hepcidin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prohepcidin, higher levels of sTfR and TIBC compared to the control group. 40% of the patients from the study group showed concentrations of ferritin below the normal range and significantly lower levels of serum iron and TfS, and significantly higher levels of sTfR, UIBC and TIBC in comparison with the rest of the study group. In this group of patients, hepcidin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prohepcidin concentrations were significantly lower than those in other patients. Conclusion: The results indicate that PV patients suffer from iron metabolism disorders. The decreased serum level of hepcidin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>prohepcidin in PV patients may be a result of iron deficiency.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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