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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.12 P.920-927


Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis

Author(s):  Mei-ying SHAO, Ping HUANG, Ran CHENG, Tao HU

Affiliation(s):  State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China

Corresponding email(s):   acomnet@263.net

Key Words:  Interleukin-6, Polymorphism, Periodontitis, Risk, Meta-analysis

Mei-ying SHAO, Ping HUANG, Ran CHENG, Tao HU. Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis[J]. Journal of Zhejiang University Science B, 2009, 10(12): 920-927.

@article{title="Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis",
author="Mei-ying SHAO, Ping HUANG, Ran CHENG, Tao HU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis
%A Mei-ying SHAO
%A Tao HU
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 12
%P 920-927
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920279

T1 - Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis
A1 - Mei-ying SHAO
A1 - Ping HUANG
A1 - Ran CHENG
A1 - Tao HU
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 12
SP - 920
EP - 927
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0920279

Objective: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. Material and methods: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 −174 G/C and −572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 −6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. Results and conclusion: The present meta-analysis indicates that the IL-6 −174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And −572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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