Full Text:   <2765>

Summary:  <1949>

CLC number: R541

On-line Access: 2015-05-04

Received: 2014-09-09

Revision Accepted: 2015-01-31

Crosschecked: 2015-04-09

Cited: 8

Clicked: 4633

Citations:  Bibtex RefMan EndNote GB/T7714


Jian-an Wang


Po Hu


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.370-379


Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

Author(s):  Po Hu, Ming-yuan Huang, Xin-yang Hu, Xiao-jie Xie, Mei-xiang Xiang, Xian-bao Liu, Jian-an Wang

Affiliation(s):  Key Laboratory for Diagnosis and Treatment of Cardiovascular Disease of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   hu999po@126.com, wja@zju.edu.cn

Key Words:  CYBA, C242T polymorphism, Acute coronary syndrome

Po Hu, Ming-yuan Huang, Xin-yang Hu, Xiao-jie Xie, Mei-xiang Xiang, Xian-bao Liu, Jian-an Wang. Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians[J]. Journal of Zhejiang University Science B, 2015, 16(5): 370-379.

@article{title="Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians",
author="Po Hu, Ming-yuan Huang, Xin-yang Hu, Xiao-jie Xie, Mei-xiang Xiang, Xian-bao Liu, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians
%A Po Hu
%A Ming-yuan Huang
%A Xin-yang Hu
%A Xiao-jie Xie
%A Mei-xiang Xiang
%A Xian-bao Liu
%A Jian-an Wang
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 5
%P 370-379
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400241

T1 - Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians
A1 - Po Hu
A1 - Ming-yuan Huang
A1 - Xin-yang Hu
A1 - Xiao-jie Xie
A1 - Mei-xiang Xiang
A1 - Xian-bao Liu
A1 - Jian-an Wang
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 5
SP - 370
EP - 379
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400241

Background: A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS. Methods and results: We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64–0.83), dominant model (OR 0.71; 95% CI 0.62–0.82), and homozygote comparison (OR 0.57; 95% CI 0.35–0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test. Conclusions: Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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