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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.12 P.918-922


Clinicopathological features of atypical lipomatous tumors of the laryngopharynx

Author(s):  Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun

Affiliation(s):  Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China, Department of Otorhinolaryngology, Chinese PLA General Hospital, Beijing 100853, China

Corresponding email(s):   shihuaiyin@sina.com

Key Words:  Atypical lipomatous tumor (ALT), Laryngopharynx, Immunohistochemistry

Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun. Clinicopathological features of atypical lipomatous tumors of the laryngopharynx[J]. Journal of Zhejiang University Science B, 2010, 11(12): 918-922.

@article{title="Clinicopathological features of atypical lipomatous tumors of the laryngopharynx",
author="Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
%A Huai-yin Shi
%A Li-xin Wei
%A Hong-tian Wang
%A Lu Sun
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 12
%P 918-922
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000164

T1 - Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
A1 - Huai-yin Shi
A1 - Li-xin Wei
A1 - Hong-tian Wang
A1 - Lu Sun
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 12
SP - 918
EP - 922
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000164

atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.

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