Full Text:   <1894>

CLC number: R73

On-line Access: 2010-12-09

Received: 2010-05-02

Revision Accepted: 2010-08-29

Crosschecked: 2010-11-16

Cited: 0

Clicked: 3934

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.12 P.918-922

http://doi.org/10.1631/jzus.B1000164


Clinicopathological features of atypical lipomatous tumors of the laryngopharynx


Author(s):  Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun

Affiliation(s):  Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China, Department of Otorhinolaryngology, Chinese PLA General Hospital, Beijing 100853, China

Corresponding email(s):   shihuaiyin@sina.com

Key Words:  Atypical lipomatous tumor (ALT), Laryngopharynx, Immunohistochemistry


Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun. Clinicopathological features of atypical lipomatous tumors of the laryngopharynx[J]. Journal of Zhejiang University Science B, 2010, 11(12): 918-922.

@article{title="Clinicopathological features of atypical lipomatous tumors of the laryngopharynx",
author="Huai-yin Shi, Li-xin Wei, Hong-tian Wang, Lu Sun",
journal="Journal of Zhejiang University Science B",
volume="11",
number="12",
pages="918-922",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000164"
}

%0 Journal Article
%T Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
%A Huai-yin Shi
%A Li-xin Wei
%A Hong-tian Wang
%A Lu Sun
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 12
%P 918-922
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000164

TY - JOUR
T1 - Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
A1 - Huai-yin Shi
A1 - Li-xin Wei
A1 - Hong-tian Wang
A1 - Lu Sun
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 12
SP - 918
EP - 922
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000164


Abstract: 
atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Arista-Nasr, J., Tapia, B., Rodriguez-Ribero, D., Magallon-Sesma, V., Hernandez, J., 1998. A case of pleomorphic lipoma of the hypopharynx. Rev. Invest. Clin., 50(3):259-261.

[2]Brauchle, R.W., Farhood, A.I., Pereira, K.D., 2001. Well-differentiated liposarcoma of the epiglottis. J. Laryngol. Otol., 115(7):593-595.

[3]Cantarella, G., Neglia, C.B., Civelli, E., Roncoroni, L., Radice, F., 2001. Spindle cell lipoma of the hypopharynx. Dysphagia, 16(3):224-227.

[4]Dal Cin, P., Kools, P., Sciot, R., de Wever, I., van Damme, B., van de Ven, W., van den Berghe, H., 1993. Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet. Cytogenet, 68(2):85-90.

[5]Dei Tos, A.P., Doglioni, C., Piccinin, S., Sciot, R., Furlanetto, A., Boiocchi, M., Dal Cin, P., Maestro, R., Fletcher, C.D., Tallini, G., 2000. Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. J. Pathol., 190(5):531-536.

[6]Fahmy, F.F., Osborne, J., Khalil, H.S., Rodgers, B., 1998. Well-differentiated liposarcoma of the hypopharynx. J. Laryngol. Otol., 112(9):880-882.

[7]Fletcher, C.D., Akerman, M., Dal Cin, P., de Wever, I., Mandahl, N., Mertens, F., Mitelman, F., Rosai, J., Rydholm, A., Sciot, R., et al., 1996. Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. Am. J. Pathol., 148(2):623-630.

[8]Fletcher, C.D.M., Nielsen, G.P., Mandahl, N., Dei Tos, A.P., Miettinen, M.M., Pedeutour, F., 2002. Adipocytic Tumours. In: Fletcher, C.D.M., Unni, K.K., Mertens, F., (Eds.), WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone, 1st Ed. IARC, Lyon, p.19-46.

[9]Jungehülsing, M., Fischbach, R., Pototschnig, C., Eckel, H.E., Damm, M., 2000. Rare benign tumors: laryngeal and hypopharyngeal lipomata. Ann. Otol. Rhinol. Laryngol., 109(3):301-305.

[10]Lippert, B.M., Eggers, S., Schlüter, E., Rudert, H., Werner, J.A., 2002. Lipoma of the larynx. Report of 2 cases and review of the literature. Otolaryngol. Pol., 56(6):669-674.

[11]Luna-Ortiz, K., Campos-Ramos, E., Carmona-Luna, T., Mohar-Betancourt, A., Ferrari-Carballo, T., 2009. Laser resection of liposarcoma of the hypopharynx. Med. Oral. Patol. Oral. Cir. Bucal., 14(5):E252-E256.

[12]Mandell, D.L., Brandwein, M.S., Woo, P., Som, P.M., Biller, H.F., Urken, M.L., 1999. Upper aerodigestive tract liposarcoma: report on four cases and literature review. Laryngoscope, 109(8):1245-1252.

[13]Mestre de Juan, M.J., Fernández-Aceñero, M.J., 1999. Laryngeal liposarcoma: report of a case. Pathol. Res. Pract., 195(2):125-128.

[14]Mouret, P., 1999. Liposarcoma of the hypopharynx. A case report and review of the literature. Rev. Laryngol. Otol. Rhinol. (Bord.), 120(1):39-42.

[15]Pedeutour, F., Forus, A., Coindre, J.M., Berner, J.M., Nicolo, G., Michiels, J.F., Terrier, P., Ranchere-Vince, D., Collin, F., Myklebost, O., et al., 1999. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer, 24(1):30-41.

[16]Persaud, R.A., Kotnis, R., Ong, C.C., Bowdler, D.A., 2002. A rare case of a pedunculated lipoma in the pharynx. Emerg. Med. J., 19(3):275.

[17]Powitzky, R., Powitzky, E.S., Garcia, R., 2007. Liposarcoma of the larynx. Ann. Otol. Rhinol. Laryngol., 116(6):418-424.

[18]Rogalla, P., Drechsler, K., Frey, G., Hennig, Y., Helmke, B., Bonk, U., Bullerdiek, J., 1996. HMGI-C expression patterns in human tissues. Implication for the genesis of frequent mesenchymal tumors. Am. J. Pathol, 149(3):775-779.

[19]Rosai, J., Akerman, M., Dal Cin, P., de Wever, I., Fletcher, C.D., Mandahl, N., Mertens, F., Mitelman, F., Rydholm, A., Sciot, R., 1996. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group). Am. J. Surg. Pathol., 20(10):1182-1189.

[20]Wambeek, N.D., Mendelson, R.M., 1996. Liposarcoma of the hypopharynx. Australas. Radiol., 40(2):165-168.

[21]Wenig, B.M., Heffner, D.K., 1995. Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of the literature. Laryngoscope, 105(7):747-756.

[22]Wenig, B.M., Weiss, S.W., Gnepp, D.R., 1990. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am. J. Surg. Pathol., 14(2):134-141.

[23]Xiao, Z.X., Chen, J., Levine, A.J., Modjtahedi, N., Xing, J., Sellers, W.R., Livingston, D.M., 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375(6533):694-697.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE